The increased ability to present citrullinated peptides is not unique to HLA-SE molecules: arginine-to-citrulline conversion also enhances peptide affinity for HLA-DQ molecules

BACKGROUND: Presentation of citrullinated neo-epitopes by HLA-DRB1 molecules that carry the shared epitope (SE) sequence was proposed to explain the association between HLA and seropositive RA. Although it is shown that several HLA-DRB1-SE molecules display enhanced binding affinities for citrullina...

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Detalles Bibliográficos
Autores principales: Kampstra, Arieke S. B., van Heemst, Jurgen, Moustakas, Antonis K., Papadopoulos, George K., Huizinga, Tom W. J., Toes, René E. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094042/
https://www.ncbi.nlm.nih.gov/pubmed/27809896
http://dx.doi.org/10.1186/s13075-016-1153-4

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