Strategies & recent development of transmission-blocking vaccines against Plasmodium falciparum

Transmission blocking malaria vaccines are aimed to block the development and maturity of sexual stages of parasite within mosquitoes. The vaccine candidate antigens (Pfs25, Pfs48/45, Pfs230) that have shown transmission blocking immunity in model systems are in different stages of development. Thes...

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Autores principales: Chaturvedi, Neha, Bharti, Praveen K., Tiwari, Archana, Singh, Neeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094109/
https://www.ncbi.nlm.nih.gov/pubmed/27748294
http://dx.doi.org/10.4103/0971-5916.191927
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author Chaturvedi, Neha
Bharti, Praveen K.
Tiwari, Archana
Singh, Neeru
author_facet Chaturvedi, Neha
Bharti, Praveen K.
Tiwari, Archana
Singh, Neeru
author_sort Chaturvedi, Neha
collection PubMed
description Transmission blocking malaria vaccines are aimed to block the development and maturity of sexual stages of parasite within mosquitoes. The vaccine candidate antigens (Pfs25, Pfs48/45, Pfs230) that have shown transmission blocking immunity in model systems are in different stages of development. These antigens are immunogenic with limited genetic diversity. Pfs25 is a leading candidate and currently in phase I clinical trial. Efforts are now focused on the cost-effective production of potent antigens using safe adjuvants and optimization of vaccine delivery system that are capable of inducing strong immune responses. This review addresses the potential usefulness, development strategies, challenges, clinical trials and current status of Plasmodium falciparum sexual stage malaria vaccine candidate antigens for the development of transmission-blocking vaccines.
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spelling pubmed-50941092016-11-23 Strategies & recent development of transmission-blocking vaccines against Plasmodium falciparum Chaturvedi, Neha Bharti, Praveen K. Tiwari, Archana Singh, Neeru Indian J Med Res Review Article Transmission blocking malaria vaccines are aimed to block the development and maturity of sexual stages of parasite within mosquitoes. The vaccine candidate antigens (Pfs25, Pfs48/45, Pfs230) that have shown transmission blocking immunity in model systems are in different stages of development. These antigens are immunogenic with limited genetic diversity. Pfs25 is a leading candidate and currently in phase I clinical trial. Efforts are now focused on the cost-effective production of potent antigens using safe adjuvants and optimization of vaccine delivery system that are capable of inducing strong immune responses. This review addresses the potential usefulness, development strategies, challenges, clinical trials and current status of Plasmodium falciparum sexual stage malaria vaccine candidate antigens for the development of transmission-blocking vaccines. Medknow Publications & Media Pvt Ltd 2016-06 /pmc/articles/PMC5094109/ /pubmed/27748294 http://dx.doi.org/10.4103/0971-5916.191927 Text en Copyright: © Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review Article
Chaturvedi, Neha
Bharti, Praveen K.
Tiwari, Archana
Singh, Neeru
Strategies & recent development of transmission-blocking vaccines against Plasmodium falciparum
title Strategies & recent development of transmission-blocking vaccines against Plasmodium falciparum
title_full Strategies & recent development of transmission-blocking vaccines against Plasmodium falciparum
title_fullStr Strategies & recent development of transmission-blocking vaccines against Plasmodium falciparum
title_full_unstemmed Strategies & recent development of transmission-blocking vaccines against Plasmodium falciparum
title_short Strategies & recent development of transmission-blocking vaccines against Plasmodium falciparum
title_sort strategies & recent development of transmission-blocking vaccines against plasmodium falciparum
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094109/
https://www.ncbi.nlm.nih.gov/pubmed/27748294
http://dx.doi.org/10.4103/0971-5916.191927
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