Tissue Transglutaminase Activates Cancer-Associated Fibroblasts and Contributes to Gemcitabine Resistance in Pancreatic Cancer()()()

Resistance to chemotherapy is a hallmark of pancreatic ductal adenocarcinoma (PDA) and has been partly attributed to the dense desmoplastic stroma, which forms a protective niche for cancer cells. Tissue transglutaminase (TG2), a Ca(2+)-dependent enzyme, is secreted by PDA cells and cross-links prot...

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Detalles Bibliográficos
Autores principales: Lee, Jiyoon, Yakubov, Bakhtiyor, Ivan, Cristina, Jones, David R., Caperell-Grant, Andrea, Fishel, Melissa, Cardenas, Horacio, Matei, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2016
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094382/
https://www.ncbi.nlm.nih.gov/pubmed/27792935
http://dx.doi.org/10.1016/j.neo.2016.09.003

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