Continuous‐Flow Synthesis and Derivatization of Aziridines through Palladium‐Catalyzed C(sp(3))−H Activation

A continuous‐flow synthesis of aziridines by palladium‐catalyzed C(sp(3))−H activation is described. The new flow reaction could be combined with an aziridine‐ring‐opening reaction to give highly functionalized aliphatic amines through a consecutive process. A predictive mechanistic model was develo...

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Autores principales: Zakrzewski, Jacek, Smalley, Adam P., Kabeshov, Mikhail A., Gaunt, Matthew J., Lapkin, Alexei A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094502/
https://www.ncbi.nlm.nih.gov/pubmed/27304395
http://dx.doi.org/10.1002/anie.201602483
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author Zakrzewski, Jacek
Smalley, Adam P.
Kabeshov, Mikhail A.
Gaunt, Matthew J.
Lapkin, Alexei A.
author_facet Zakrzewski, Jacek
Smalley, Adam P.
Kabeshov, Mikhail A.
Gaunt, Matthew J.
Lapkin, Alexei A.
author_sort Zakrzewski, Jacek
collection PubMed
description A continuous‐flow synthesis of aziridines by palladium‐catalyzed C(sp(3))−H activation is described. The new flow reaction could be combined with an aziridine‐ring‐opening reaction to give highly functionalized aliphatic amines through a consecutive process. A predictive mechanistic model was developed and used to design the C−H activation flow process and illustrates an approach towards first‐principles design based on novel catalytic reactions.
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spelling pubmed-50945022016-11-09 Continuous‐Flow Synthesis and Derivatization of Aziridines through Palladium‐Catalyzed C(sp(3))−H Activation Zakrzewski, Jacek Smalley, Adam P. Kabeshov, Mikhail A. Gaunt, Matthew J. Lapkin, Alexei A. Angew Chem Int Ed Engl Communications A continuous‐flow synthesis of aziridines by palladium‐catalyzed C(sp(3))−H activation is described. The new flow reaction could be combined with an aziridine‐ring‐opening reaction to give highly functionalized aliphatic amines through a consecutive process. A predictive mechanistic model was developed and used to design the C−H activation flow process and illustrates an approach towards first‐principles design based on novel catalytic reactions. John Wiley and Sons Inc. 2016-06-15 2016-07-25 /pmc/articles/PMC5094502/ /pubmed/27304395 http://dx.doi.org/10.1002/anie.201602483 Text en © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Zakrzewski, Jacek
Smalley, Adam P.
Kabeshov, Mikhail A.
Gaunt, Matthew J.
Lapkin, Alexei A.
Continuous‐Flow Synthesis and Derivatization of Aziridines through Palladium‐Catalyzed C(sp(3))−H Activation
title Continuous‐Flow Synthesis and Derivatization of Aziridines through Palladium‐Catalyzed C(sp(3))−H Activation
title_full Continuous‐Flow Synthesis and Derivatization of Aziridines through Palladium‐Catalyzed C(sp(3))−H Activation
title_fullStr Continuous‐Flow Synthesis and Derivatization of Aziridines through Palladium‐Catalyzed C(sp(3))−H Activation
title_full_unstemmed Continuous‐Flow Synthesis and Derivatization of Aziridines through Palladium‐Catalyzed C(sp(3))−H Activation
title_short Continuous‐Flow Synthesis and Derivatization of Aziridines through Palladium‐Catalyzed C(sp(3))−H Activation
title_sort continuous‐flow synthesis and derivatization of aziridines through palladium‐catalyzed c(sp(3))−h activation
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094502/
https://www.ncbi.nlm.nih.gov/pubmed/27304395
http://dx.doi.org/10.1002/anie.201602483
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