Non‐tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia

Composition of tumour immune cell infiltrates correlates with response to treatment and overall survival (OS) in several cancer settings. We retrospectively examined immune cells present in diagnostic bone marrow aspirates from paediatric patients with B‐cell acute lymphoblastic leukaemia. Our analy...

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Detalles Bibliográficos
Autores principales: Edwin, Claire, Dean, Joanne, Bonnett, Laura, Phillips, Kate, Keenan, Russell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094538/
https://www.ncbi.nlm.nih.gov/pubmed/27348401
http://dx.doi.org/10.1002/pbc.26093
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author Edwin, Claire
Dean, Joanne
Bonnett, Laura
Phillips, Kate
Keenan, Russell
author_facet Edwin, Claire
Dean, Joanne
Bonnett, Laura
Phillips, Kate
Keenan, Russell
author_sort Edwin, Claire
collection PubMed
description Composition of tumour immune cell infiltrates correlates with response to treatment and overall survival (OS) in several cancer settings. We retrospectively examined immune cells present in diagnostic bone marrow aspirates from paediatric patients with B‐cell acute lymphoblastic leukaemia. Our analysis identified a sub‐group (∼30% of patients) with >2.37% CD20 and >6.05% CD7 expression, which had 100% OS, and a sub‐group (∼30% of patients) with ≤2.37% CD20 and ≤6.05% CD7 expression at increased risk of treatment failure (66.7% OS, P < 0.05). Immune cell infiltrate at diagnosis may predict treatment response and could provide a means to enhance immediate treatment risk stratification.
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spelling pubmed-50945382016-11-09 Non‐tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia Edwin, Claire Dean, Joanne Bonnett, Laura Phillips, Kate Keenan, Russell Pediatr Blood Cancer Brief Reports Composition of tumour immune cell infiltrates correlates with response to treatment and overall survival (OS) in several cancer settings. We retrospectively examined immune cells present in diagnostic bone marrow aspirates from paediatric patients with B‐cell acute lymphoblastic leukaemia. Our analysis identified a sub‐group (∼30% of patients) with >2.37% CD20 and >6.05% CD7 expression, which had 100% OS, and a sub‐group (∼30% of patients) with ≤2.37% CD20 and ≤6.05% CD7 expression at increased risk of treatment failure (66.7% OS, P < 0.05). Immune cell infiltrate at diagnosis may predict treatment response and could provide a means to enhance immediate treatment risk stratification. John Wiley and Sons Inc. 2016-06-27 2016-10 /pmc/articles/PMC5094538/ /pubmed/27348401 http://dx.doi.org/10.1002/pbc.26093 Text en © 2016 The Authors. Pediatric Blood & Cancer, published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Edwin, Claire
Dean, Joanne
Bonnett, Laura
Phillips, Kate
Keenan, Russell
Non‐tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia
title Non‐tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia
title_full Non‐tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia
title_fullStr Non‐tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia
title_full_unstemmed Non‐tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia
title_short Non‐tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia
title_sort non‐tumour bone marrow lymphocytes correlate with improved overall survival in childhood acute lymphoblastic leukaemia
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094538/
https://www.ncbi.nlm.nih.gov/pubmed/27348401
http://dx.doi.org/10.1002/pbc.26093
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