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Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial

Morin (2´,3, 4´,5,7-pentahydroxyflavone) is a flavonoid with several beneficial health effects. However, its poor water solubility and it sensitivity to several environmental factors avoid its use in applications like pharmaceutical and cosmetic. In this work, we synthetized morin-modified mesoporou...

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Autores principales: Arriagada, Francisco, Correa, Olosmira, Günther, Germán, Nonell, Santi, Mura, Francisco, Olea-Azar, Claudio, Morales, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094702/
https://www.ncbi.nlm.nih.gov/pubmed/27812111
http://dx.doi.org/10.1371/journal.pone.0164507
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author Arriagada, Francisco
Correa, Olosmira
Günther, Germán
Nonell, Santi
Mura, Francisco
Olea-Azar, Claudio
Morales, Javier
author_facet Arriagada, Francisco
Correa, Olosmira
Günther, Germán
Nonell, Santi
Mura, Francisco
Olea-Azar, Claudio
Morales, Javier
author_sort Arriagada, Francisco
collection PubMed
description Morin (2´,3, 4´,5,7-pentahydroxyflavone) is a flavonoid with several beneficial health effects. However, its poor water solubility and it sensitivity to several environmental factors avoid its use in applications like pharmaceutical and cosmetic. In this work, we synthetized morin-modified mesoporous silica nanoparticles (AMSNPs-MOR) as useful material to be used as potential nanoantioxidant. To achieve this, we characterized its adsorption kinetics, isotherm and the antioxidant capacity as hydroxyl radical (HO•) scavenger and singlet oxygen ((1)O(2)) quencher. The experimental data could be well fitted with Langmuir, Freundlich and Temkin isotherm models, besides the pseudo-second order kinetics model. The total quenching rate constant obtained for singlet oxygen deactivation by AMSNPs-MOR was one order of magnitude lower than the morin rate constant reported previously in neat solvents and lipid membranes. The AMSNPs-MOR have good antioxidant properties by itself and exhibit a synergic effect with morin on the antioxidant property against hydroxyl radical. This effect, in the range of concentrations studied, was increased when the amount of morin adsorbed increased.
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spelling pubmed-50947022016-11-18 Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial Arriagada, Francisco Correa, Olosmira Günther, Germán Nonell, Santi Mura, Francisco Olea-Azar, Claudio Morales, Javier PLoS One Research Article Morin (2´,3, 4´,5,7-pentahydroxyflavone) is a flavonoid with several beneficial health effects. However, its poor water solubility and it sensitivity to several environmental factors avoid its use in applications like pharmaceutical and cosmetic. In this work, we synthetized morin-modified mesoporous silica nanoparticles (AMSNPs-MOR) as useful material to be used as potential nanoantioxidant. To achieve this, we characterized its adsorption kinetics, isotherm and the antioxidant capacity as hydroxyl radical (HO•) scavenger and singlet oxygen ((1)O(2)) quencher. The experimental data could be well fitted with Langmuir, Freundlich and Temkin isotherm models, besides the pseudo-second order kinetics model. The total quenching rate constant obtained for singlet oxygen deactivation by AMSNPs-MOR was one order of magnitude lower than the morin rate constant reported previously in neat solvents and lipid membranes. The AMSNPs-MOR have good antioxidant properties by itself and exhibit a synergic effect with morin on the antioxidant property against hydroxyl radical. This effect, in the range of concentrations studied, was increased when the amount of morin adsorbed increased. Public Library of Science 2016-11-03 /pmc/articles/PMC5094702/ /pubmed/27812111 http://dx.doi.org/10.1371/journal.pone.0164507 Text en © 2016 Arriagada et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Arriagada, Francisco
Correa, Olosmira
Günther, Germán
Nonell, Santi
Mura, Francisco
Olea-Azar, Claudio
Morales, Javier
Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial
title Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial
title_full Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial
title_fullStr Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial
title_full_unstemmed Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial
title_short Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant Nanomaterial
title_sort morin flavonoid adsorbed on mesoporous silica, a novel antioxidant nanomaterial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094702/
https://www.ncbi.nlm.nih.gov/pubmed/27812111
http://dx.doi.org/10.1371/journal.pone.0164507
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