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Development of the Intrinsic Language Network in Preschool Children from Ages 3 to 5 Years
Resting state studies of spontaneous fluctuations in the functional magnetic resonance imaging (fMRI) blood oxygen level dependent signal have shown great potential in mapping the intrinsic functional connectivity of the human brain underlying cognitive functions. The aim of the present study was to...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094780/ https://www.ncbi.nlm.nih.gov/pubmed/27812160 http://dx.doi.org/10.1371/journal.pone.0165802 |
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author | Xiao, Yaqiong Brauer, Jens Lauckner, Mark Zhai, Hongchang Jia, Fucang Margulies, Daniel S. Friederici, Angela D. |
author_facet | Xiao, Yaqiong Brauer, Jens Lauckner, Mark Zhai, Hongchang Jia, Fucang Margulies, Daniel S. Friederici, Angela D. |
author_sort | Xiao, Yaqiong |
collection | PubMed |
description | Resting state studies of spontaneous fluctuations in the functional magnetic resonance imaging (fMRI) blood oxygen level dependent signal have shown great potential in mapping the intrinsic functional connectivity of the human brain underlying cognitive functions. The aim of the present study was to explore the developmental changes in functional networks of the developing human brain exemplified with the language network in typically developing preschool children. To this end, resting-sate fMRI data were obtained from native Chinese children at ages of 3 and 5 years, 15 in each age group. Resting-state functional connectivity (RSFC) was analyzed for four regions of interest; these are the left and right anterior superior temporal gyrus (aSTG), left posterior superior temporal gyrus (pSTG), and left inferior frontal gyrus (IFG). The comparison of these RSFC maps between 3- and 5-year-olds revealed that RSFC decreases in the right aSTG and increases in the left hemisphere between aSTG seed and IFG, between pSTG seed and IFG, as well as between IFG seed and posterior superior temporal sulcus. In a subsequent analysis, functional asymmetry of the language network seeding in aSTG, pSTG and IFG was further investigated. The results showed an increase of left lateralization in both RSFC of pSTG and of IFG from ages 3 to 5 years. The IFG showed a leftward lateralized trend in 3-year-olds, while pSTG demonstrated rightward asymmetry in 5-year-olds. These findings suggest clear developmental trajectories of the language network between 3- and 5-year-olds revealed as a function of age, characterized by increasing long-range connections and dynamic hemispheric lateralization with age. Our study provides new insights into the developmental changes of a well-established functional network in young children and also offers a basis for future cross-culture and cross-age studies of the resting-state language network. |
format | Online Article Text |
id | pubmed-5094780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-50947802016-11-18 Development of the Intrinsic Language Network in Preschool Children from Ages 3 to 5 Years Xiao, Yaqiong Brauer, Jens Lauckner, Mark Zhai, Hongchang Jia, Fucang Margulies, Daniel S. Friederici, Angela D. PLoS One Research Article Resting state studies of spontaneous fluctuations in the functional magnetic resonance imaging (fMRI) blood oxygen level dependent signal have shown great potential in mapping the intrinsic functional connectivity of the human brain underlying cognitive functions. The aim of the present study was to explore the developmental changes in functional networks of the developing human brain exemplified with the language network in typically developing preschool children. To this end, resting-sate fMRI data were obtained from native Chinese children at ages of 3 and 5 years, 15 in each age group. Resting-state functional connectivity (RSFC) was analyzed for four regions of interest; these are the left and right anterior superior temporal gyrus (aSTG), left posterior superior temporal gyrus (pSTG), and left inferior frontal gyrus (IFG). The comparison of these RSFC maps between 3- and 5-year-olds revealed that RSFC decreases in the right aSTG and increases in the left hemisphere between aSTG seed and IFG, between pSTG seed and IFG, as well as between IFG seed and posterior superior temporal sulcus. In a subsequent analysis, functional asymmetry of the language network seeding in aSTG, pSTG and IFG was further investigated. The results showed an increase of left lateralization in both RSFC of pSTG and of IFG from ages 3 to 5 years. The IFG showed a leftward lateralized trend in 3-year-olds, while pSTG demonstrated rightward asymmetry in 5-year-olds. These findings suggest clear developmental trajectories of the language network between 3- and 5-year-olds revealed as a function of age, characterized by increasing long-range connections and dynamic hemispheric lateralization with age. Our study provides new insights into the developmental changes of a well-established functional network in young children and also offers a basis for future cross-culture and cross-age studies of the resting-state language network. Public Library of Science 2016-11-03 /pmc/articles/PMC5094780/ /pubmed/27812160 http://dx.doi.org/10.1371/journal.pone.0165802 Text en © 2016 Xiao et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Xiao, Yaqiong Brauer, Jens Lauckner, Mark Zhai, Hongchang Jia, Fucang Margulies, Daniel S. Friederici, Angela D. Development of the Intrinsic Language Network in Preschool Children from Ages 3 to 5 Years |
title | Development of the Intrinsic Language Network in Preschool Children from Ages 3 to 5 Years |
title_full | Development of the Intrinsic Language Network in Preschool Children from Ages 3 to 5 Years |
title_fullStr | Development of the Intrinsic Language Network in Preschool Children from Ages 3 to 5 Years |
title_full_unstemmed | Development of the Intrinsic Language Network in Preschool Children from Ages 3 to 5 Years |
title_short | Development of the Intrinsic Language Network in Preschool Children from Ages 3 to 5 Years |
title_sort | development of the intrinsic language network in preschool children from ages 3 to 5 years |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094780/ https://www.ncbi.nlm.nih.gov/pubmed/27812160 http://dx.doi.org/10.1371/journal.pone.0165802 |
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