Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation

Imprime PGG (Imprime), an intravenously-administered, soluble β-glucan, has shown compelling efficacy in multiple phase 2 clinical trials with tumor targeting or anti-angiogenic antibodies. Mechanistically, Imprime acts as pathogen-associated molecular pattern (PAMP) directly activating innate immun...

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Detalles Bibliográficos
Autores principales: Chan, Anissa S. H., Jonas, Adria Bykowski, Qiu, Xiaohong, Ottoson, Nadine R., Walsh, Richard M., Gorden, Keith B, Harrison, Ben, Maimonis, Peter J., Leonardo, Steven M., Ertelt, Kathleen E., Danielson, Michael E., Michel, Kyle S., Nelson, Mariana, Graff, Jeremy R., Patchen, Myra L., Bose, Nandita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094785/
https://www.ncbi.nlm.nih.gov/pubmed/27812183
http://dx.doi.org/10.1371/journal.pone.0165909

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