Dual mTORC1/2 inhibition induces anti-proliferative effect in NF1-associated plexiform neurofibroma and malignant peripheral nerve sheath tumor cells

Approximately 30-50% of individuals with Neurofibromatosis type 1 develop benign peripheral nerve sheath tumors, called plexiform neurofibromas (PNFs). PNFs can undergo malignant transformation to highly metastatic malignant peripheral nerve sheath tumors (MPNSTs) in 5-10% of NF1 patients, with poor...

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Detalles Bibliográficos
Autores principales: Varin, Jennifer, Poulain, Laury, Hivelin, Mikael, Nusbaum, Patrick, Hubas, Arnaud, Laurendeau, Ingrid, Lantieri, Laurent, Wolkenstein, Pierre, Vidaud, Michel, Pasmant, Eric, Chapuis, Nicolas, Parfait, Béatrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094959/
https://www.ncbi.nlm.nih.gov/pubmed/26840085
http://dx.doi.org/10.18632/oncotarget.7099

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