Clinical and genetic features of lung squamous cell cancer in never-smokers

To evaluate the importance of specific driver mutations to the development and outcome of lung squamous cell cancer (SQCC) in never-smokers, we assessed the clinicopathological characteristics and outcomes of 597 patients who underwent complete resection of SQCCs. In total, 88 (14.7%) never-smokers...

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Detalles Bibliográficos
Autores principales: Huang, Yangle, Wang, Rui, Pan, Yunjian, Zhang, Yang, Li, Hang, Cheng, Chao, Zheng, Difan, Zheng, Shanbo, Li, Yuan, Shen, Xuxia, Hu, Haichuan, Cai, Deng, Wang, Shengfei, Zhang, Yawei, Xiang, Jiaqing, Sun, Yihua, Zhang, Jie, Chen, Haiquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094976/
https://www.ncbi.nlm.nih.gov/pubmed/27092882
http://dx.doi.org/10.18632/oncotarget.8745
Descripción
Sumario:To evaluate the importance of specific driver mutations to the development and outcome of lung squamous cell cancer (SQCC) in never-smokers, we assessed the clinicopathological characteristics and outcomes of 597 patients who underwent complete resection of SQCCs. In total, 88 (14.7%) never-smokers and 509 (85.3%) ever-smokers were compared. The never-smokers included more females (42.05% vs. 1.57%, P < 0.001) and more often had a personal history of malignant disease (9.09% vs. 2.36%, P = 0.003). The tumors of never-smokers were more often poorly differentiated (70.45% vs. 53.24%, P = 0.010) and more often contained oncogenic mutations (21.05% vs 11.05%, P = 0.023), particularly EGFR mutations (13.16% vs 3.40%, P = 0.001). Never-smokers also tended to have poorer OS than smokers. Our results suggest lung SQCCs in never-smokers are a subtype distinct from SQCCs occurring in smokers.

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