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Defective STAT1 activation associated with impaired IFN-γ production in NK and T lymphocytes from metastatic melanoma patients treated with IL-2

High dose (HD) IL-2 therapy has been used for almost two decades as an immunotherapy for metastatic melanoma. IL-2 promotes the proliferation and effector function of T and NK cells through the tyrosine phosphorylation and activation of signal transducer and activator of transcription factors (STAT)...

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Detalles Bibliográficos
Autores principales:	Sim, Geok Choo, Wu, Sheng, Jin, Lei, Hwu, Patrick, Radvanyi, Laszlo G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094984/ https://www.ncbi.nlm.nih.gov/pubmed/27153543 http://dx.doi.org/10.18632/oncotarget.8683

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