Reduced miR-200b and miR-200c expression contributes to abnormal hepatic lipid accumulation by stimulating JUN expression and activating the transcription of srebp1

Previous studies indicated that miR-200s participated in IL-6-induced hepatic insulin resistance. However, the role of miR-200s in hepatic lipid accumulation has not been elucidated. Here we found that miR-200b and miR-200c were reduced in the steatotic livers of mice fed a high-fat diet (HFD) and p...

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Detalles Bibliográficos
Autores principales: Guo, Jun, Fang, Weiwei, Sun, Libo, Lu, Yonggang, Dou, Lin, Huang, Xiuqing, Sun, Mingxiao, Pang, Cheng, Qu, Jing, Liu, Guanghui, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094994/
https://www.ncbi.nlm.nih.gov/pubmed/27166182
http://dx.doi.org/10.18632/oncotarget.9183

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