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Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils

Devil facial tumour disease (DFTD) is a recently emerged fatal transmissible cancer decimating the wild population of Tasmanian devils (Sarcophilus harrisii). Biting transmits the cancer cells and the tumour develops in the new host as an allograft. The literature reports that immune escape mechanis...

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Autores principales: Pye, Ruth, Hamede, Rodrigo, Siddle, Hannah V., Caldwell, Alison, Knowles, Graeme W., Swift, Kate, Kreiss, Alexandre, Jones, Menna E., Lyons, A. Bruce, Woods, Gregory M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095191/
https://www.ncbi.nlm.nih.gov/pubmed/28120799
http://dx.doi.org/10.1098/rsbl.2016.0553
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author Pye, Ruth
Hamede, Rodrigo
Siddle, Hannah V.
Caldwell, Alison
Knowles, Graeme W.
Swift, Kate
Kreiss, Alexandre
Jones, Menna E.
Lyons, A. Bruce
Woods, Gregory M.
author_facet Pye, Ruth
Hamede, Rodrigo
Siddle, Hannah V.
Caldwell, Alison
Knowles, Graeme W.
Swift, Kate
Kreiss, Alexandre
Jones, Menna E.
Lyons, A. Bruce
Woods, Gregory M.
author_sort Pye, Ruth
collection PubMed
description Devil facial tumour disease (DFTD) is a recently emerged fatal transmissible cancer decimating the wild population of Tasmanian devils (Sarcophilus harrisii). Biting transmits the cancer cells and the tumour develops in the new host as an allograft. The literature reports that immune escape mechanisms employed by DFTD inevitably result in host death. Here we present the first evidence that DFTD regression can occur and that wild devils can mount an immune response against the disease. Of the 52 devils tested, six had serum antibodies against DFTD cells and, in one case, prominent T lymphocyte infiltration in its tumour. Notably, four of the six devils with serum antibody had histories of DFTD regression. The novel demonstration of an immune response against DFTD in wild Tasmanian devils suggests that a proportion of wild devils can produce a protective immune response against naturally acquired DFTD. This has implications for tumour–host coevolution and vaccine development.
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spelling pubmed-50951912016-11-10 Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils Pye, Ruth Hamede, Rodrigo Siddle, Hannah V. Caldwell, Alison Knowles, Graeme W. Swift, Kate Kreiss, Alexandre Jones, Menna E. Lyons, A. Bruce Woods, Gregory M. Biol Lett Conservation Biology Devil facial tumour disease (DFTD) is a recently emerged fatal transmissible cancer decimating the wild population of Tasmanian devils (Sarcophilus harrisii). Biting transmits the cancer cells and the tumour develops in the new host as an allograft. The literature reports that immune escape mechanisms employed by DFTD inevitably result in host death. Here we present the first evidence that DFTD regression can occur and that wild devils can mount an immune response against the disease. Of the 52 devils tested, six had serum antibodies against DFTD cells and, in one case, prominent T lymphocyte infiltration in its tumour. Notably, four of the six devils with serum antibody had histories of DFTD regression. The novel demonstration of an immune response against DFTD in wild Tasmanian devils suggests that a proportion of wild devils can produce a protective immune response against naturally acquired DFTD. This has implications for tumour–host coevolution and vaccine development. The Royal Society 2016-10 /pmc/articles/PMC5095191/ /pubmed/28120799 http://dx.doi.org/10.1098/rsbl.2016.0553 Text en © 2016 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Conservation Biology
Pye, Ruth
Hamede, Rodrigo
Siddle, Hannah V.
Caldwell, Alison
Knowles, Graeme W.
Swift, Kate
Kreiss, Alexandre
Jones, Menna E.
Lyons, A. Bruce
Woods, Gregory M.
Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils
title Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils
title_full Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils
title_fullStr Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils
title_full_unstemmed Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils
title_short Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils
title_sort demonstration of immune responses against devil facial tumour disease in wild tasmanian devils
topic Conservation Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095191/
https://www.ncbi.nlm.nih.gov/pubmed/28120799
http://dx.doi.org/10.1098/rsbl.2016.0553
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