Cargando…
Quantifying unobserved protein-coding variants in human populations provides a roadmap for large-scale sequencing projects
As new proposals aim to sequence ever larger collection of humans, it is critical to have a quantitative framework to evaluate the statistical power of these projects. We developed a new algorithm, UnseenEst, and applied it to the exomes of 60,706 individuals to estimate the frequency distribution o...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095512/ https://www.ncbi.nlm.nih.gov/pubmed/27796292 http://dx.doi.org/10.1038/ncomms13293 |