Disposal of iron by a mutant form of lipocalin 2

Iron overload damages many organs. Unfortunately, therapeutic iron chelators also have undesired toxicity and may deliver iron to microbes. Here we show that a mutant form (K3Cys) of endogenous lipocalin 2 (LCN2) is filtered by the kidney but can bypass sites of megalin-dependent recapture, resultin...

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Detalles Bibliográficos
Autores principales: Barasch, Jonathan, Hollmen, Maria, Deng, Rong, Hod, Eldad A., Rupert, Peter B., Abergel, Rebecca J., Allred, Benjamin E., Xu, Katherine, Darrah, Shaun F., Tekabe, Yared, Perlstein, Alan, Wax, Rebecca, Bruck, Efrat, Stauber, Jacob, Corbin, Kaitlyn A., Buchen, Charles, Slavkovich, Vesna, Graziano, Joseph, Spitalnik, Steven L., Bao, Guanhu, Strong, Roland K., Qiu, Andong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095531/
https://www.ncbi.nlm.nih.gov/pubmed/27796299
http://dx.doi.org/10.1038/ncomms12973

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