PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation

Despite the global impact of macrophage activation in vascular disease, the underlying mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage cell lines treated with either IFNγ or IL-4, that PARP9 and PARP14 regulate macrophage activation. In primary macrophages, PARP...

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Detalles Bibliográficos
Autores principales: Iwata, Hiroshi, Goettsch, Claudia, Sharma, Amitabh, Ricchiuto, Piero, Goh, Wilson Wen Bin, Halu, Arda, Yamada, Iwao, Yoshida, Hideo, Hara, Takuya, Wei, Mei, Inoue, Noriyuki, Fukuda, Daiju, Mojcher, Alexander, Mattson, Peter C., Barabási, Albert-László, Boothby, Mark, Aikawa, Elena, Singh, Sasha A., Aikawa, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095532/
https://www.ncbi.nlm.nih.gov/pubmed/27796300
http://dx.doi.org/10.1038/ncomms12849

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