EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

Epidermal growth factor receptor (EGFR) signalling is activated by ligand-induced receptor dimerization. Notably, ligand binding also induces EGFR oligomerization, but the structures and functions of the oligomers are poorly understood. Here, we use fluorophore localization imaging with photobleachi...

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Detalles Bibliográficos
Autores principales: Needham, Sarah R., Roberts, Selene K., Arkhipov, Anton, Mysore, Venkatesh P., Tynan, Christopher J., Zanetti-Domingues, Laura C., Kim, Eric T., Losasso, Valeria, Korovesis, Dimitrios, Hirsch, Michael, Rolfe, Daniel J., Clarke, David T., Winn, Martyn D., Lajevardipour, Alireza, Clayton, Andrew H. A., Pike, Linda J., Perani, Michela, Parker, Peter J., Shan, Yibing, Shaw, David E., Martin-Fernandez, Marisa L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095584/
https://www.ncbi.nlm.nih.gov/pubmed/27796308
http://dx.doi.org/10.1038/ncomms13307

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