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Association of Mannose-binding Lectin Polymorphisms with Tuberculosis Susceptibility among Chinese
Tuberculosis (TB) is caused by infection of Mycobacterium tuberculosis. Host genetic variability is an important determinant of the risk of developing TB in humans. Although the association between MBL2 polymorphisms and TB has been studied in various populations, the results are controversial. In t...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095599/ https://www.ncbi.nlm.nih.gov/pubmed/27812036 http://dx.doi.org/10.1038/srep36488 |
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author | Liu, Cheng He, Tao Rong, Yanxiao Du, Fengjiao Ma, Dongxing Wei, Yujie Mei, Zhiqin Wang, Yuling Wang, Haibin Zhu, Yuehua Zhang, Zongde Zheng, Li Wu, Xueqiong Liu, Huiliang Ding, Wenjun |
author_facet | Liu, Cheng He, Tao Rong, Yanxiao Du, Fengjiao Ma, Dongxing Wei, Yujie Mei, Zhiqin Wang, Yuling Wang, Haibin Zhu, Yuehua Zhang, Zongde Zheng, Li Wu, Xueqiong Liu, Huiliang Ding, Wenjun |
author_sort | Liu, Cheng |
collection | PubMed |
description | Tuberculosis (TB) is caused by infection of Mycobacterium tuberculosis. Host genetic variability is an important determinant of the risk of developing TB in humans. Although the association between MBL2 polymorphisms and TB has been studied in various populations, the results are controversial. In this study four functional single-nucleotide polymorphisms (SNPs, H/L, X/Y, P/Q and A/B) across the MBL2 gene were genotyped by direct DNA sequencing of PCR products in a case-control population of Chinese Han origin, consisting of 1,020 patients with pulmonary TB and 1,020 controls. We found that individuals carrying variant allele at A/B (namely BB or AB genotypes) was associated with increased susceptibility to TB (odds ratios [OR] = 1.57, 95% confidence interval [CI] 1.30–1.91, P = 1.3 × 10(−6)). Additionally, LYPB haplotype showed a significant association with increased risk of TB (OR = 1.54, 95% CI 1.27–1.87, P = 4.2 × 10(−6); global haplotype association P = 3.5 × 10(−5)). Furthermore, individuals bearing low- or medium- MBL expression haplotype pairs had an increased risk of TB (OR = 1.56, 95% CI 1.29–1.90, P = 1.4 × 10(−6)). Thus, the reduced expression of functional MBL secondary to having MBL2 variants may partially mediate the increased susceptibility to TB risk. |
format | Online Article Text |
id | pubmed-5095599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50955992016-11-10 Association of Mannose-binding Lectin Polymorphisms with Tuberculosis Susceptibility among Chinese Liu, Cheng He, Tao Rong, Yanxiao Du, Fengjiao Ma, Dongxing Wei, Yujie Mei, Zhiqin Wang, Yuling Wang, Haibin Zhu, Yuehua Zhang, Zongde Zheng, Li Wu, Xueqiong Liu, Huiliang Ding, Wenjun Sci Rep Article Tuberculosis (TB) is caused by infection of Mycobacterium tuberculosis. Host genetic variability is an important determinant of the risk of developing TB in humans. Although the association between MBL2 polymorphisms and TB has been studied in various populations, the results are controversial. In this study four functional single-nucleotide polymorphisms (SNPs, H/L, X/Y, P/Q and A/B) across the MBL2 gene were genotyped by direct DNA sequencing of PCR products in a case-control population of Chinese Han origin, consisting of 1,020 patients with pulmonary TB and 1,020 controls. We found that individuals carrying variant allele at A/B (namely BB or AB genotypes) was associated with increased susceptibility to TB (odds ratios [OR] = 1.57, 95% confidence interval [CI] 1.30–1.91, P = 1.3 × 10(−6)). Additionally, LYPB haplotype showed a significant association with increased risk of TB (OR = 1.54, 95% CI 1.27–1.87, P = 4.2 × 10(−6); global haplotype association P = 3.5 × 10(−5)). Furthermore, individuals bearing low- or medium- MBL expression haplotype pairs had an increased risk of TB (OR = 1.56, 95% CI 1.29–1.90, P = 1.4 × 10(−6)). Thus, the reduced expression of functional MBL secondary to having MBL2 variants may partially mediate the increased susceptibility to TB risk. Nature Publishing Group 2016-11-04 /pmc/articles/PMC5095599/ /pubmed/27812036 http://dx.doi.org/10.1038/srep36488 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Liu, Cheng He, Tao Rong, Yanxiao Du, Fengjiao Ma, Dongxing Wei, Yujie Mei, Zhiqin Wang, Yuling Wang, Haibin Zhu, Yuehua Zhang, Zongde Zheng, Li Wu, Xueqiong Liu, Huiliang Ding, Wenjun Association of Mannose-binding Lectin Polymorphisms with Tuberculosis Susceptibility among Chinese |
title | Association of Mannose-binding Lectin Polymorphisms with Tuberculosis Susceptibility among Chinese |
title_full | Association of Mannose-binding Lectin Polymorphisms with Tuberculosis Susceptibility among Chinese |
title_fullStr | Association of Mannose-binding Lectin Polymorphisms with Tuberculosis Susceptibility among Chinese |
title_full_unstemmed | Association of Mannose-binding Lectin Polymorphisms with Tuberculosis Susceptibility among Chinese |
title_short | Association of Mannose-binding Lectin Polymorphisms with Tuberculosis Susceptibility among Chinese |
title_sort | association of mannose-binding lectin polymorphisms with tuberculosis susceptibility among chinese |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095599/ https://www.ncbi.nlm.nih.gov/pubmed/27812036 http://dx.doi.org/10.1038/srep36488 |
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