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Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy

Cancer cells express tumour-specific antigens derived via genetic and epigenetic alterations, which may be targeted by T-cell-mediated immune responses. However, cancer cells can avoid immune surveillance by suppressing immunity through activation of specific inhibitory signalling pathways, referred...

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Detalles Bibliográficos
Autores principales:	Lee, Ju Yeon, Lee, Hyun Tae, Shin, Woori, Chae, Jongseok, Choi, Jaemo, Kim, Sung Hyun, Lim, Heejin, Won Heo, Tae, Park, Kyeong Young, Lee, Yeon Ji, Ryu, Seong Eon, Son, Ji Young, Lee, Jee Un, Heo, Yong-Seok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095608/ https://www.ncbi.nlm.nih.gov/pubmed/27796306 http://dx.doi.org/10.1038/ncomms13354

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