Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog

A 2-year-old female beagle was referred to our hospital for evaluation of anemia. Laboratory tests, including bone marrow cytology, revealed non-regenerative immune-mediated anemia (NRIMA). Although initial immunosuppressive multi-drug therapy was not effective, additional administration of danazol...

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Detalles Bibliográficos
Autores principales: KOBAYASHI, Kosuke, Shimokawa MIYAMA, Takako, ITAMOTO, Kazuhito, NOGUCHI, Shunsuke, BABA, Kenji, MIZUNO, Takuya, OKUDA, Masaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2016
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095632/
https://www.ncbi.nlm.nih.gov/pubmed/27320967
http://dx.doi.org/10.1292/jvms.16-0019
Descripción
Sumario:A 2-year-old female beagle was referred to our hospital for evaluation of anemia. Laboratory tests, including bone marrow cytology, revealed non-regenerative immune-mediated anemia (NRIMA). Although initial immunosuppressive multi-drug therapy was not effective, additional administration of danazol was successful in treating the anemia. However, hepatocellular carcinoma (HCC) developed about 20 months after the administration of danazol. In humans, several cases of development of HCC after the administration of danazol have been reported. The present report describes a case of HCC development in a dog after chronic administration of danazol in addition to other immunosuppressive drugs.

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