Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog

A 2-year-old female beagle was referred to our hospital for evaluation of anemia. Laboratory tests, including bone marrow cytology, revealed non-regenerative immune-mediated anemia (NRIMA). Although initial immunosuppressive multi-drug therapy was not effective, additional administration of danazol...

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Autores principales: KOBAYASHI, Kosuke, Shimokawa MIYAMA, Takako, ITAMOTO, Kazuhito, NOGUCHI, Shunsuke, BABA, Kenji, MIZUNO, Takuya, OKUDA, Masaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2016
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095632/
https://www.ncbi.nlm.nih.gov/pubmed/27320967
http://dx.doi.org/10.1292/jvms.16-0019
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author KOBAYASHI, Kosuke
Shimokawa MIYAMA, Takako
ITAMOTO, Kazuhito
NOGUCHI, Shunsuke
BABA, Kenji
MIZUNO, Takuya
OKUDA, Masaru
author_facet KOBAYASHI, Kosuke
Shimokawa MIYAMA, Takako
ITAMOTO, Kazuhito
NOGUCHI, Shunsuke
BABA, Kenji
MIZUNO, Takuya
OKUDA, Masaru
author_sort KOBAYASHI, Kosuke
collection PubMed
description A 2-year-old female beagle was referred to our hospital for evaluation of anemia. Laboratory tests, including bone marrow cytology, revealed non-regenerative immune-mediated anemia (NRIMA). Although initial immunosuppressive multi-drug therapy was not effective, additional administration of danazol was successful in treating the anemia. However, hepatocellular carcinoma (HCC) developed about 20 months after the administration of danazol. In humans, several cases of development of HCC after the administration of danazol have been reported. The present report describes a case of HCC development in a dog after chronic administration of danazol in addition to other immunosuppressive drugs.
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spelling pubmed-50956322016-11-07 Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog KOBAYASHI, Kosuke Shimokawa MIYAMA, Takako ITAMOTO, Kazuhito NOGUCHI, Shunsuke BABA, Kenji MIZUNO, Takuya OKUDA, Masaru J Vet Med Sci Internal Medicine A 2-year-old female beagle was referred to our hospital for evaluation of anemia. Laboratory tests, including bone marrow cytology, revealed non-regenerative immune-mediated anemia (NRIMA). Although initial immunosuppressive multi-drug therapy was not effective, additional administration of danazol was successful in treating the anemia. However, hepatocellular carcinoma (HCC) developed about 20 months after the administration of danazol. In humans, several cases of development of HCC after the administration of danazol have been reported. The present report describes a case of HCC development in a dog after chronic administration of danazol in addition to other immunosuppressive drugs. The Japanese Society of Veterinary Science 2016-06-20 2016-10 /pmc/articles/PMC5095632/ /pubmed/27320967 http://dx.doi.org/10.1292/jvms.16-0019 Text en ©2016 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Internal Medicine
KOBAYASHI, Kosuke
Shimokawa MIYAMA, Takako
ITAMOTO, Kazuhito
NOGUCHI, Shunsuke
BABA, Kenji
MIZUNO, Takuya
OKUDA, Masaru
Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog
title Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog
title_full Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog
title_fullStr Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog
title_full_unstemmed Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog
title_short Development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog
title_sort development of hepatocellular carcinoma after long-term immunosuppressive therapy including danazol in a dog
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095632/
https://www.ncbi.nlm.nih.gov/pubmed/27320967
http://dx.doi.org/10.1292/jvms.16-0019
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