Retargeted Foamy Virus Vectors Integrate Less Frequently Near Proto-oncogenes

Retroviral gene therapy offers immense potential to treat many genetic diseases and has already shown efficacy in clinical trials. However, retroviral vector mediated genotoxicity remains a major challenge and clinically relevant approaches to reduce integration near genes and proto-oncogenes are ne...

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Detalles Bibliográficos
Autores principales: Hocum, Jonah D., Linde, Ian, Rae, Dustin T., Collins, Casey P., Matern, Lindsay K., Trobridge, Grant D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095648/
https://www.ncbi.nlm.nih.gov/pubmed/27812034
http://dx.doi.org/10.1038/srep36610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095648/
https://www.ncbi.nlm.nih.gov/pubmed/27812034
http://dx.doi.org/10.1038/srep36610

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