Antioxidative Polyketones from the Mangrove-Derived Fungus Ascomycota sp. SK2YWS-L

Three novel 2,3-diaryl indone derivatives, ascomindones A−C (1−3), and two new isobenzofuran derivatives, ascomfurans A (4) and B (5), together with four know compounds (6−9) were isolated from the culture of a mangrove-derived fungus Ascomycota sp. SK2YWS-L. Their structures were elucidated on the...

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Autores principales: Tan, Chunbin, Liu, Zhaoming, Chen, Senhua, Huang, Xishan, Cui, Hui, Long, Yuhua, Lu, Yongjun, She, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095669/
https://www.ncbi.nlm.nih.gov/pubmed/27811993
http://dx.doi.org/10.1038/srep36609
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author Tan, Chunbin
Liu, Zhaoming
Chen, Senhua
Huang, Xishan
Cui, Hui
Long, Yuhua
Lu, Yongjun
She, Zhigang
author_facet Tan, Chunbin
Liu, Zhaoming
Chen, Senhua
Huang, Xishan
Cui, Hui
Long, Yuhua
Lu, Yongjun
She, Zhigang
author_sort Tan, Chunbin
collection PubMed
description Three novel 2,3-diaryl indone derivatives, ascomindones A−C (1−3), and two new isobenzofuran derivatives, ascomfurans A (4) and B (5), together with four know compounds (6−9) were isolated from the culture of a mangrove-derived fungus Ascomycota sp. SK2YWS-L. Their structures were elucidated on the interpretation of spectroscopic data. 1 and 4 were further constructed by analysis of X-ray diffraction. Antioxidant properties based on 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radical scavenging activities and the ferric reducing ability power (FRAP) of the new compounds were assayed. All of them exhibited significant effects, of which 1 showed more potent activity than ascorbic acid in scavenging DPPH radical with IC(50) value of 18.1 μM.
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spelling pubmed-50956692016-11-10 Antioxidative Polyketones from the Mangrove-Derived Fungus Ascomycota sp. SK2YWS-L Tan, Chunbin Liu, Zhaoming Chen, Senhua Huang, Xishan Cui, Hui Long, Yuhua Lu, Yongjun She, Zhigang Sci Rep Article Three novel 2,3-diaryl indone derivatives, ascomindones A−C (1−3), and two new isobenzofuran derivatives, ascomfurans A (4) and B (5), together with four know compounds (6−9) were isolated from the culture of a mangrove-derived fungus Ascomycota sp. SK2YWS-L. Their structures were elucidated on the interpretation of spectroscopic data. 1 and 4 were further constructed by analysis of X-ray diffraction. Antioxidant properties based on 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radical scavenging activities and the ferric reducing ability power (FRAP) of the new compounds were assayed. All of them exhibited significant effects, of which 1 showed more potent activity than ascorbic acid in scavenging DPPH radical with IC(50) value of 18.1 μM. Nature Publishing Group 2016-11-04 /pmc/articles/PMC5095669/ /pubmed/27811993 http://dx.doi.org/10.1038/srep36609 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Tan, Chunbin
Liu, Zhaoming
Chen, Senhua
Huang, Xishan
Cui, Hui
Long, Yuhua
Lu, Yongjun
She, Zhigang
Antioxidative Polyketones from the Mangrove-Derived Fungus Ascomycota sp. SK2YWS-L
title Antioxidative Polyketones from the Mangrove-Derived Fungus Ascomycota sp. SK2YWS-L
title_full Antioxidative Polyketones from the Mangrove-Derived Fungus Ascomycota sp. SK2YWS-L
title_fullStr Antioxidative Polyketones from the Mangrove-Derived Fungus Ascomycota sp. SK2YWS-L
title_full_unstemmed Antioxidative Polyketones from the Mangrove-Derived Fungus Ascomycota sp. SK2YWS-L
title_short Antioxidative Polyketones from the Mangrove-Derived Fungus Ascomycota sp. SK2YWS-L
title_sort antioxidative polyketones from the mangrove-derived fungus ascomycota sp. sk2yws-l
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095669/
https://www.ncbi.nlm.nih.gov/pubmed/27811993
http://dx.doi.org/10.1038/srep36609
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