Cargando…
Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students
ABSTRACT: Synapses are essential components of neurons and allow information to travel coordinately throughout the nervous system to adjust behavior to environmental stimuli and to control body functions, memories, and emotions. Thus, optimal synaptic communication is required for proper brain physi...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095804/ https://www.ncbi.nlm.nih.gov/pubmed/27333343 http://dx.doi.org/10.1111/jnc.13713 |
_version_ | 1782465351316930560 |
---|---|
author | Lepeta, Katarzyna Lourenco, Mychael V. Schweitzer, Barbara C. Martino Adami, Pamela V. Banerjee, Priyanjalee Catuara‐Solarz, Silvina de La Fuente Revenga, Mario Guillem, Alain Marc Haidar, Mouna Ijomone, Omamuyovwi M. Nadorp, Bettina Qi, Lin Perera, Nirma D. Refsgaard, Louise K. Reid, Kimberley M. Sabbar, Mariam Sahoo, Arghyadip Schaefer, Natascha Sheean, Rebecca K. Suska, Anna Verma, Rajkumar Vicidomini, Cinzia Wright, Dean Zhang, Xing‐Ding Seidenbecher, Constanze |
author_facet | Lepeta, Katarzyna Lourenco, Mychael V. Schweitzer, Barbara C. Martino Adami, Pamela V. Banerjee, Priyanjalee Catuara‐Solarz, Silvina de La Fuente Revenga, Mario Guillem, Alain Marc Haidar, Mouna Ijomone, Omamuyovwi M. Nadorp, Bettina Qi, Lin Perera, Nirma D. Refsgaard, Louise K. Reid, Kimberley M. Sabbar, Mariam Sahoo, Arghyadip Schaefer, Natascha Sheean, Rebecca K. Suska, Anna Verma, Rajkumar Vicidomini, Cinzia Wright, Dean Zhang, Xing‐Ding Seidenbecher, Constanze |
author_sort | Lepeta, Katarzyna |
collection | PubMed |
description | ABSTRACT: Synapses are essential components of neurons and allow information to travel coordinately throughout the nervous system to adjust behavior to environmental stimuli and to control body functions, memories, and emotions. Thus, optimal synaptic communication is required for proper brain physiology, and slight perturbations of synapse function can lead to brain disorders. In fact, increasing evidence has demonstrated the relevance of synapse dysfunction as a major determinant of many neurological diseases. This notion has led to the concept of synaptopathies as brain diseases with synapse defects as shared pathogenic features. In this review, which was initiated at the 13th International Society for Neurochemistry Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental disorders (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer and Parkinson disease). We finally discuss the appropriateness and potential implications of gathering synapse diseases under a single term. Understanding common causes and intrinsic differences in disease‐associated synaptic dysfunction could offer novel clues toward synapse‐based therapeutic intervention for neurological and neuropsychiatric disorders. [Image: see text] In this Review, which was initiated at the 13th International Society for Neurochemistry (ISN) Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer's and Parkinson's diseases), gathered together under the term of synaptopathies. Read the Editorial Highlight for this article on page 783. |
format | Online Article Text |
id | pubmed-5095804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50958042016-11-09 Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students Lepeta, Katarzyna Lourenco, Mychael V. Schweitzer, Barbara C. Martino Adami, Pamela V. Banerjee, Priyanjalee Catuara‐Solarz, Silvina de La Fuente Revenga, Mario Guillem, Alain Marc Haidar, Mouna Ijomone, Omamuyovwi M. Nadorp, Bettina Qi, Lin Perera, Nirma D. Refsgaard, Louise K. Reid, Kimberley M. Sabbar, Mariam Sahoo, Arghyadip Schaefer, Natascha Sheean, Rebecca K. Suska, Anna Verma, Rajkumar Vicidomini, Cinzia Wright, Dean Zhang, Xing‐Ding Seidenbecher, Constanze J Neurochem Highlighted Article ABSTRACT: Synapses are essential components of neurons and allow information to travel coordinately throughout the nervous system to adjust behavior to environmental stimuli and to control body functions, memories, and emotions. Thus, optimal synaptic communication is required for proper brain physiology, and slight perturbations of synapse function can lead to brain disorders. In fact, increasing evidence has demonstrated the relevance of synapse dysfunction as a major determinant of many neurological diseases. This notion has led to the concept of synaptopathies as brain diseases with synapse defects as shared pathogenic features. In this review, which was initiated at the 13th International Society for Neurochemistry Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental disorders (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer and Parkinson disease). We finally discuss the appropriateness and potential implications of gathering synapse diseases under a single term. Understanding common causes and intrinsic differences in disease‐associated synaptic dysfunction could offer novel clues toward synapse‐based therapeutic intervention for neurological and neuropsychiatric disorders. [Image: see text] In this Review, which was initiated at the 13th International Society for Neurochemistry (ISN) Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer's and Parkinson's diseases), gathered together under the term of synaptopathies. Read the Editorial Highlight for this article on page 783. John Wiley and Sons Inc. 2016-09-08 2016-09 /pmc/articles/PMC5095804/ /pubmed/27333343 http://dx.doi.org/10.1111/jnc.13713 Text en © 2016 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Highlighted Article Lepeta, Katarzyna Lourenco, Mychael V. Schweitzer, Barbara C. Martino Adami, Pamela V. Banerjee, Priyanjalee Catuara‐Solarz, Silvina de La Fuente Revenga, Mario Guillem, Alain Marc Haidar, Mouna Ijomone, Omamuyovwi M. Nadorp, Bettina Qi, Lin Perera, Nirma D. Refsgaard, Louise K. Reid, Kimberley M. Sabbar, Mariam Sahoo, Arghyadip Schaefer, Natascha Sheean, Rebecca K. Suska, Anna Verma, Rajkumar Vicidomini, Cinzia Wright, Dean Zhang, Xing‐Ding Seidenbecher, Constanze Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students |
title | Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students |
title_full | Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students |
title_fullStr | Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students |
title_full_unstemmed | Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students |
title_short | Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students |
title_sort | synaptopathies: synaptic dysfunction in neurological disorders – a review from students to students |
topic | Highlighted Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095804/ https://www.ncbi.nlm.nih.gov/pubmed/27333343 http://dx.doi.org/10.1111/jnc.13713 |
work_keys_str_mv | AT lepetakatarzyna synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT lourencomychaelv synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT schweitzerbarbarac synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT martinoadamipamelav synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT banerjeepriyanjalee synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT catuarasolarzsilvina synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT delafuenterevengamario synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT guillemalainmarc synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT haidarmouna synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT ijomoneomamuyovwim synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT nadorpbettina synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT qilin synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT pereranirmad synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT refsgaardlouisek synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT reidkimberleym synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT sabbarmariam synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT sahooarghyadip synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT schaefernatascha synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT sheeanrebeccak synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT suskaanna synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT vermarajkumar synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT vicidominicinzia synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT wrightdean synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT zhangxingding synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents AT seidenbecherconstanze synaptopathiessynapticdysfunctioninneurologicaldisordersareviewfromstudentstostudents |