Constraining an Irregular Peptide Secondary Structure through Ring‐Closing Alkyne Metathesis

Macrocyclization can be used to constrain peptides in their bioactive conformations, thereby supporting target affinity and bioactivity. In particular, for the targeting of challenging protein–protein interactions, macrocyclic peptides have proven to be very useful. Available approaches focus on the...

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Detalles Bibliográficos
Autores principales: Cromm, Philipp M., Wallraven, Kerstin, Glas, Adrian, Bier, David, Fürstner, Alois, Ottmann, Christian, Grossmann, Tom N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096054/
https://www.ncbi.nlm.nih.gov/pubmed/27596722
http://dx.doi.org/10.1002/cbic.201600362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096054/
https://www.ncbi.nlm.nih.gov/pubmed/27596722
http://dx.doi.org/10.1002/cbic.201600362

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