1,5‐Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid‐β(1‐40) Fibrillization

Biologically relevant 1,5‐diazacyclooctanes derived from polyamines and acrolein, inhibit Aβ40 peptide fibrillization and significantly suppress cell cytotoxicity. Formal [4+4] cycloaddition reaction of imines is thus involved in modulating oxidative stress processes associated with neural diseases....

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Detalles Bibliográficos
Autores principales: Tsutsui, Ayumi, Zako, Tamotsu, Bu, Tong, Yamaguchi, Yoshiki, Maeda, Mizuo, Tanaka, Katsunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096251/
https://www.ncbi.nlm.nih.gov/pubmed/27840798
http://dx.doi.org/10.1002/advs.201600082
Descripción
Sumario:Biologically relevant 1,5‐diazacyclooctanes derived from polyamines and acrolein, inhibit Aβ40 peptide fibrillization and significantly suppress cell cytotoxicity. Formal [4+4] cycloaddition reaction of imines is thus involved in modulating oxidative stress processes associated with neural diseases. [Image: see text]

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