1,5‐Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid‐β(1‐40) Fibrillization

Biologically relevant 1,5‐diazacyclooctanes derived from polyamines and acrolein, inhibit Aβ40 peptide fibrillization and significantly suppress cell cytotoxicity. Formal [4+4] cycloaddition reaction of imines is thus involved in modulating oxidative stress processes associated with neural diseases....

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Detalles Bibliográficos
Autores principales: Tsutsui, Ayumi, Zako, Tamotsu, Bu, Tong, Yamaguchi, Yoshiki, Maeda, Mizuo, Tanaka, Katsunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096251/
https://www.ncbi.nlm.nih.gov/pubmed/27840798
http://dx.doi.org/10.1002/advs.201600082
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author Tsutsui, Ayumi
Zako, Tamotsu
Bu, Tong
Yamaguchi, Yoshiki
Maeda, Mizuo
Tanaka, Katsunori
author_facet Tsutsui, Ayumi
Zako, Tamotsu
Bu, Tong
Yamaguchi, Yoshiki
Maeda, Mizuo
Tanaka, Katsunori
author_sort Tsutsui, Ayumi
collection PubMed
description Biologically relevant 1,5‐diazacyclooctanes derived from polyamines and acrolein, inhibit Aβ40 peptide fibrillization and significantly suppress cell cytotoxicity. Formal [4+4] cycloaddition reaction of imines is thus involved in modulating oxidative stress processes associated with neural diseases. [Image: see text]
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spelling pubmed-50962512016-11-09 1,5‐Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid‐β(1‐40) Fibrillization Tsutsui, Ayumi Zako, Tamotsu Bu, Tong Yamaguchi, Yoshiki Maeda, Mizuo Tanaka, Katsunori Adv Sci (Weinh) Communications Biologically relevant 1,5‐diazacyclooctanes derived from polyamines and acrolein, inhibit Aβ40 peptide fibrillization and significantly suppress cell cytotoxicity. Formal [4+4] cycloaddition reaction of imines is thus involved in modulating oxidative stress processes associated with neural diseases. [Image: see text] John Wiley and Sons Inc. 2016-06-01 /pmc/articles/PMC5096251/ /pubmed/27840798 http://dx.doi.org/10.1002/advs.201600082 Text en © 2016 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Tsutsui, Ayumi
Zako, Tamotsu
Bu, Tong
Yamaguchi, Yoshiki
Maeda, Mizuo
Tanaka, Katsunori
1,5‐Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid‐β(1‐40) Fibrillization
title 1,5‐Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid‐β(1‐40) Fibrillization
title_full 1,5‐Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid‐β(1‐40) Fibrillization
title_fullStr 1,5‐Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid‐β(1‐40) Fibrillization
title_full_unstemmed 1,5‐Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid‐β(1‐40) Fibrillization
title_short 1,5‐Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid‐β(1‐40) Fibrillization
title_sort 1,5‐diazacyclooctanes, as exclusive oxidative polyamine metabolites, inhibit amyloid‐β(1‐40) fibrillization
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096251/
https://www.ncbi.nlm.nih.gov/pubmed/27840798
http://dx.doi.org/10.1002/advs.201600082
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