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1,5‐Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid‐β(1‐40) Fibrillization

Biologically relevant 1,5‐diazacyclooctanes derived from polyamines and acrolein, inhibit Aβ40 peptide fibrillization and significantly suppress cell cytotoxicity. Formal [4+4] cycloaddition reaction of imines is thus involved in modulating oxidative stress processes associated with neural diseases....

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Detalles Bibliográficos
Autores principales:	Tsutsui, Ayumi, Zako, Tamotsu, Bu, Tong, Yamaguchi, Yoshiki, Maeda, Mizuo, Tanaka, Katsunori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096251/ https://www.ncbi.nlm.nih.gov/pubmed/27840798 http://dx.doi.org/10.1002/advs.201600082

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