Non enzymatic upregulation of tissue factor expression by gamma-glutamyl transferase in human peripheral blood mononuclear cells

BACKGROUND: Besides maintaining intracellular glutathione stores, gamma-glutamyltransferase(GGT) generates reactive oxygen species and activates NFkB, a redox-sensitive transcription factor key in the induction of Tissue Factor (TF) gene expression, the principal initiator of the clotting cascade. T...

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Detalles Bibliográficos
Autores principales: Scalise, Valentina, Balia, Cristina, Cianchetti, Silvana, Neri, Tommaso, Carnicelli, Vittoria, Zucchi, Riccardo, Franzini, Maria, Corti, Alessandro, Paolicchi, Aldo, Celi, Alessandro, Pedrinelli, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096335/
https://www.ncbi.nlm.nih.gov/pubmed/27822142
http://dx.doi.org/10.1186/s12959-016-0119-8

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