Cargando…

Evaluation of Silent Myocardial Ischemia with Single-Photon Emission Computed Tomography/Computed Tomography in Asymptomatic Subjects with Diabetes and Pre-Diabetes

OBJECTIVE: The aim of this study was to disclose the prevalence of myocardial ischemia, as detected by adenosine stress myocardial perfusion imaging (MPI) with hybrid single-photon emission computed tomography/computed tomography (SPECT/CT), in asymptomatic diabetic and pre-diabetic patients and to...

Descripción completa

Detalles Bibliográficos
Autores principales: Özdemir, Elif, Burçak Polat, Şefika, Yıldırım, Nilüfer, Türkölmez, Şeyda, Ersoy, Reyhan, Durmaz, Tahir, Keleş, Telat, Bozkurt, Engin, Çakır, Bekir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096623/
https://www.ncbi.nlm.nih.gov/pubmed/27277323
http://dx.doi.org/10.4274/mirt.24633
_version_ 1782465496743936000
author Özdemir, Elif
Burçak Polat, Şefika
Yıldırım, Nilüfer
Türkölmez, Şeyda
Ersoy, Reyhan
Durmaz, Tahir
Keleş, Telat
Bozkurt, Engin
Çakır, Bekir
author_facet Özdemir, Elif
Burçak Polat, Şefika
Yıldırım, Nilüfer
Türkölmez, Şeyda
Ersoy, Reyhan
Durmaz, Tahir
Keleş, Telat
Bozkurt, Engin
Çakır, Bekir
author_sort Özdemir, Elif
collection PubMed
description OBJECTIVE: The aim of this study was to disclose the prevalence of myocardial ischemia, as detected by adenosine stress myocardial perfusion imaging (MPI) with hybrid single-photon emission computed tomography/computed tomography (SPECT/CT), in asymptomatic diabetic and pre-diabetic patients and to find out whether ischemia predicted the occurrence of adverse cardiac/cerebrovascular events (ACCE) at follow-up. METHODS: Forty-three diabetic and thirty-five pre-diabetic asymptomatic patients without any history of coronary artery disease, underwent MPI and were followed-up for a 12.8±2.2 (8-19) months for the occurrence of ACCE. Baseline variables that would predict the presence of ischemia and the value of ischemia on MPI for predicting the occurrence of ACCE at follow-up were evaluated by logistic regression analysis. RESULTS: Ischemia was detected in ten (23.3%) of the diabetic and in four (11.4%) of the pre-diabetic patients. The presence of diabetes was the only independent predictor of myocardial ischemia [odds ratio (OR): 12.31, 95% confidence interval (CI): 1.83-82.66; p<0.01]. During 12.8±2.2 (8-19) months of follow-up, ACCE was observed in five out of 78 (6.4%) patients. Patients with ischemia were significantly more likely to have ACCE during follow-up as compared to those with normal MPI scans (event rates: 21.4% vs. 3.1%, OR: 8.455 95% CI: 1.264-56.562, p=0.038). CONCLUSION: Myocardial ischemia as detected by adenosine stress SPECT/CT in a population of asymptomatic patients with diabetes mellitus or pre-diabetes appeared to predict the occurrence of ACCE at follow-up.
format Online
Article
Text
id pubmed-5096623
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Galenos Publishing
record_format MEDLINE/PubMed
spelling pubmed-50966232016-11-14 Evaluation of Silent Myocardial Ischemia with Single-Photon Emission Computed Tomography/Computed Tomography in Asymptomatic Subjects with Diabetes and Pre-Diabetes Özdemir, Elif Burçak Polat, Şefika Yıldırım, Nilüfer Türkölmez, Şeyda Ersoy, Reyhan Durmaz, Tahir Keleş, Telat Bozkurt, Engin Çakır, Bekir Mol Imaging Radionucl Ther Original Article OBJECTIVE: The aim of this study was to disclose the prevalence of myocardial ischemia, as detected by adenosine stress myocardial perfusion imaging (MPI) with hybrid single-photon emission computed tomography/computed tomography (SPECT/CT), in asymptomatic diabetic and pre-diabetic patients and to find out whether ischemia predicted the occurrence of adverse cardiac/cerebrovascular events (ACCE) at follow-up. METHODS: Forty-three diabetic and thirty-five pre-diabetic asymptomatic patients without any history of coronary artery disease, underwent MPI and were followed-up for a 12.8±2.2 (8-19) months for the occurrence of ACCE. Baseline variables that would predict the presence of ischemia and the value of ischemia on MPI for predicting the occurrence of ACCE at follow-up were evaluated by logistic regression analysis. RESULTS: Ischemia was detected in ten (23.3%) of the diabetic and in four (11.4%) of the pre-diabetic patients. The presence of diabetes was the only independent predictor of myocardial ischemia [odds ratio (OR): 12.31, 95% confidence interval (CI): 1.83-82.66; p<0.01]. During 12.8±2.2 (8-19) months of follow-up, ACCE was observed in five out of 78 (6.4%) patients. Patients with ischemia were significantly more likely to have ACCE during follow-up as compared to those with normal MPI scans (event rates: 21.4% vs. 3.1%, OR: 8.455 95% CI: 1.264-56.562, p=0.038). CONCLUSION: Myocardial ischemia as detected by adenosine stress SPECT/CT in a population of asymptomatic patients with diabetes mellitus or pre-diabetes appeared to predict the occurrence of ACCE at follow-up. Galenos Publishing 2016-06 2016-06-06 /pmc/articles/PMC5096623/ /pubmed/27277323 http://dx.doi.org/10.4274/mirt.24633 Text en © Molecular Imaging and Radionuclide Therapy, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Özdemir, Elif
Burçak Polat, Şefika
Yıldırım, Nilüfer
Türkölmez, Şeyda
Ersoy, Reyhan
Durmaz, Tahir
Keleş, Telat
Bozkurt, Engin
Çakır, Bekir
Evaluation of Silent Myocardial Ischemia with Single-Photon Emission Computed Tomography/Computed Tomography in Asymptomatic Subjects with Diabetes and Pre-Diabetes
title Evaluation of Silent Myocardial Ischemia with Single-Photon Emission Computed Tomography/Computed Tomography in Asymptomatic Subjects with Diabetes and Pre-Diabetes
title_full Evaluation of Silent Myocardial Ischemia with Single-Photon Emission Computed Tomography/Computed Tomography in Asymptomatic Subjects with Diabetes and Pre-Diabetes
title_fullStr Evaluation of Silent Myocardial Ischemia with Single-Photon Emission Computed Tomography/Computed Tomography in Asymptomatic Subjects with Diabetes and Pre-Diabetes
title_full_unstemmed Evaluation of Silent Myocardial Ischemia with Single-Photon Emission Computed Tomography/Computed Tomography in Asymptomatic Subjects with Diabetes and Pre-Diabetes
title_short Evaluation of Silent Myocardial Ischemia with Single-Photon Emission Computed Tomography/Computed Tomography in Asymptomatic Subjects with Diabetes and Pre-Diabetes
title_sort evaluation of silent myocardial ischemia with single-photon emission computed tomography/computed tomography in asymptomatic subjects with diabetes and pre-diabetes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096623/
https://www.ncbi.nlm.nih.gov/pubmed/27277323
http://dx.doi.org/10.4274/mirt.24633
work_keys_str_mv AT ozdemirelif evaluationofsilentmyocardialischemiawithsinglephotonemissioncomputedtomographycomputedtomographyinasymptomaticsubjectswithdiabetesandprediabetes
AT burcakpolatsefika evaluationofsilentmyocardialischemiawithsinglephotonemissioncomputedtomographycomputedtomographyinasymptomaticsubjectswithdiabetesandprediabetes
AT yıldırımnilufer evaluationofsilentmyocardialischemiawithsinglephotonemissioncomputedtomographycomputedtomographyinasymptomaticsubjectswithdiabetesandprediabetes
AT turkolmezseyda evaluationofsilentmyocardialischemiawithsinglephotonemissioncomputedtomographycomputedtomographyinasymptomaticsubjectswithdiabetesandprediabetes
AT ersoyreyhan evaluationofsilentmyocardialischemiawithsinglephotonemissioncomputedtomographycomputedtomographyinasymptomaticsubjectswithdiabetesandprediabetes
AT durmaztahir evaluationofsilentmyocardialischemiawithsinglephotonemissioncomputedtomographycomputedtomographyinasymptomaticsubjectswithdiabetesandprediabetes
AT kelestelat evaluationofsilentmyocardialischemiawithsinglephotonemissioncomputedtomographycomputedtomographyinasymptomaticsubjectswithdiabetesandprediabetes
AT bozkurtengin evaluationofsilentmyocardialischemiawithsinglephotonemissioncomputedtomographycomputedtomographyinasymptomaticsubjectswithdiabetesandprediabetes
AT cakırbekir evaluationofsilentmyocardialischemiawithsinglephotonemissioncomputedtomographycomputedtomographyinasymptomaticsubjectswithdiabetesandprediabetes