Regional expression of the MAPT gene is associated with loss of hubs in brain networks and cognitive impairment in Parkinson disease and progressive supranuclear palsy

Abnormalities of tau protein are central to the pathogenesis of progressive supranuclear palsy, whereas haplotype variation of the tau gene MAPT influences the risk of Parkinson disease and Parkinson's disease dementia. We assessed whether regional MAPT expression might be associated with selec...

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Detalles Bibliográficos
Autores principales: Rittman, Timothy, Rubinov, Mikail, Vértes, Petra E., Patel, Ameera X., Ginestet, Cedric E., Ghosh, Boyd C.P., Barker, Roger A., Spillantini, Maria Grazia, Bullmore, Edward T., Rowe, James B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096886/
https://www.ncbi.nlm.nih.gov/pubmed/27697694
http://dx.doi.org/10.1016/j.neurobiolaging.2016.09.001

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