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Core 1- and core 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice
Core 1- and core 3-derived mucin-type O-glycans are primary components of the mucus layer in the colon. Reduced mucus thickness and impaired O-glycosylation are observed in human ulcerative colitis. However, how both types of O-glycans maintain mucus barrier function in the colon is unclear. We foun...
Autores principales: | Bergstrom, Kirk, Fu, Jianxin, Johansson, Malin EV, Liu, Xiaowei, Gao, Nan, Wu, Qian, Song, Jianhua, McDaniel, J Michael, McGee, Samuel, Chen, Weichang, Braun, Jonathan, Hansson, Gunnar C, Xia, Lijun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097036/ https://www.ncbi.nlm.nih.gov/pubmed/27143302 http://dx.doi.org/10.1038/mi.2016.45 |
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