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Epigenetic reprogramming of the zygote in mice and men: on your marks, get set, go!

Gametogenesis (spermatogenesis and oogenesis) is accompanied by the acquisition of gender-specific epigenetic marks, such as DNA methylation, histone modifications and regulation by small RNAs, to form highly differentiated, but transcriptionally silent cell-types in preparation for fertilisation. U...

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Detalles Bibliográficos
Autores principales: Fraser, Rupsha, Lin, Chih-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097126/
https://www.ncbi.nlm.nih.gov/pubmed/27601712
http://dx.doi.org/10.1530/REP-16-0376
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author Fraser, Rupsha
Lin, Chih-Jen
author_facet Fraser, Rupsha
Lin, Chih-Jen
author_sort Fraser, Rupsha
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description Gametogenesis (spermatogenesis and oogenesis) is accompanied by the acquisition of gender-specific epigenetic marks, such as DNA methylation, histone modifications and regulation by small RNAs, to form highly differentiated, but transcriptionally silent cell-types in preparation for fertilisation. Upon fertilisation, extensive global epigenetic reprogramming takes place to remove the previously acquired epigenetic marks and produce totipotent zygotic states. It is the aim of this review to delineate the cellular and molecular events involved in maternal, paternal and zygotic epigenetic reprogramming from the time of gametogenesis, through fertilisation, to the initiation of zygotic genome activation for preimplantation embryonic development. Recent studies have begun to uncover the indispensable functions of epigenetic players during gametogenesis, fertilisation and preimplantation embryo development, and a more comprehensive understanding of these early events will be informative for increasing pregnancy success rates, adding particular value to assisted fertility programmes.
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spelling pubmed-50971262016-12-19 Epigenetic reprogramming of the zygote in mice and men: on your marks, get set, go! Fraser, Rupsha Lin, Chih-Jen Reproduction Review Gametogenesis (spermatogenesis and oogenesis) is accompanied by the acquisition of gender-specific epigenetic marks, such as DNA methylation, histone modifications and regulation by small RNAs, to form highly differentiated, but transcriptionally silent cell-types in preparation for fertilisation. Upon fertilisation, extensive global epigenetic reprogramming takes place to remove the previously acquired epigenetic marks and produce totipotent zygotic states. It is the aim of this review to delineate the cellular and molecular events involved in maternal, paternal and zygotic epigenetic reprogramming from the time of gametogenesis, through fertilisation, to the initiation of zygotic genome activation for preimplantation embryonic development. Recent studies have begun to uncover the indispensable functions of epigenetic players during gametogenesis, fertilisation and preimplantation embryo development, and a more comprehensive understanding of these early events will be informative for increasing pregnancy success rates, adding particular value to assisted fertility programmes. Bioscientifica Ltd 2016-10-20 /pmc/articles/PMC5097126/ /pubmed/27601712 http://dx.doi.org/10.1530/REP-16-0376 Text en © 2016 The authors http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Review
Fraser, Rupsha
Lin, Chih-Jen
Epigenetic reprogramming of the zygote in mice and men: on your marks, get set, go!
title Epigenetic reprogramming of the zygote in mice and men: on your marks, get set, go!
title_full Epigenetic reprogramming of the zygote in mice and men: on your marks, get set, go!
title_fullStr Epigenetic reprogramming of the zygote in mice and men: on your marks, get set, go!
title_full_unstemmed Epigenetic reprogramming of the zygote in mice and men: on your marks, get set, go!
title_short Epigenetic reprogramming of the zygote in mice and men: on your marks, get set, go!
title_sort epigenetic reprogramming of the zygote in mice and men: on your marks, get set, go!
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097126/
https://www.ncbi.nlm.nih.gov/pubmed/27601712
http://dx.doi.org/10.1530/REP-16-0376
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