Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria

Dendritic cells have an important role in immune surveillance. After being exposed to microbial components, they migrate to secondary lymphoid organs and activate T lymphocytes. Here we show that during mouse malaria, splenic inflammatory monocytes differentiate into monocyte-derived dendritic cells...

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Autores principales: Hirako, Isabella C., Ataide, Marco A., Faustino, Lucas, Assis, Patricia A., Sorensen, Elizabeth W., Ueta, Hisashi, Araújo, Natalia M., Menezes, Gustavo B., Luster, Andrew D., Gazzinelli, Ricardo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097164/
https://www.ncbi.nlm.nih.gov/pubmed/27808089
http://dx.doi.org/10.1038/ncomms13277
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author Hirako, Isabella C.
Ataide, Marco A.
Faustino, Lucas
Assis, Patricia A.
Sorensen, Elizabeth W.
Ueta, Hisashi
Araújo, Natalia M.
Menezes, Gustavo B.
Luster, Andrew D.
Gazzinelli, Ricardo T.
author_facet Hirako, Isabella C.
Ataide, Marco A.
Faustino, Lucas
Assis, Patricia A.
Sorensen, Elizabeth W.
Ueta, Hisashi
Araújo, Natalia M.
Menezes, Gustavo B.
Luster, Andrew D.
Gazzinelli, Ricardo T.
author_sort Hirako, Isabella C.
collection PubMed
description Dendritic cells have an important role in immune surveillance. After being exposed to microbial components, they migrate to secondary lymphoid organs and activate T lymphocytes. Here we show that during mouse malaria, splenic inflammatory monocytes differentiate into monocyte-derived dendritic cells (MO-DCs), which are CD11b(+)F4/80(+)CD11c(+)MHCII(high)DC-SIGN(high)Ly6c(+) and express high levels of CCR5, CXCL9 and CXCL10 (CCR5(+)CXCL9/10(+) MO-DCs). We propose that malaria-induced splenic MO-DCs take a reverse migratory route. After differentiation in the spleen, CCR5(+)CXCL9/10(+) MO-DCs traffic to the brain in a CCR2-independent, CCR5-dependent manner, where they amplify the influx of CD8(+) T lymphocytes, leading to a lethal neuropathological syndrome.
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spelling pubmed-50971642016-11-18 Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria Hirako, Isabella C. Ataide, Marco A. Faustino, Lucas Assis, Patricia A. Sorensen, Elizabeth W. Ueta, Hisashi Araújo, Natalia M. Menezes, Gustavo B. Luster, Andrew D. Gazzinelli, Ricardo T. Nat Commun Article Dendritic cells have an important role in immune surveillance. After being exposed to microbial components, they migrate to secondary lymphoid organs and activate T lymphocytes. Here we show that during mouse malaria, splenic inflammatory monocytes differentiate into monocyte-derived dendritic cells (MO-DCs), which are CD11b(+)F4/80(+)CD11c(+)MHCII(high)DC-SIGN(high)Ly6c(+) and express high levels of CCR5, CXCL9 and CXCL10 (CCR5(+)CXCL9/10(+) MO-DCs). We propose that malaria-induced splenic MO-DCs take a reverse migratory route. After differentiation in the spleen, CCR5(+)CXCL9/10(+) MO-DCs traffic to the brain in a CCR2-independent, CCR5-dependent manner, where they amplify the influx of CD8(+) T lymphocytes, leading to a lethal neuropathological syndrome. Nature Publishing Group 2016-11-03 /pmc/articles/PMC5097164/ /pubmed/27808089 http://dx.doi.org/10.1038/ncomms13277 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Hirako, Isabella C.
Ataide, Marco A.
Faustino, Lucas
Assis, Patricia A.
Sorensen, Elizabeth W.
Ueta, Hisashi
Araújo, Natalia M.
Menezes, Gustavo B.
Luster, Andrew D.
Gazzinelli, Ricardo T.
Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria
title Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria
title_full Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria
title_fullStr Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria
title_full_unstemmed Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria
title_short Splenic differentiation and emergence of CCR5(+)CXCL9(+)CXCL10(+) monocyte-derived dendritic cells in the brain during cerebral malaria
title_sort splenic differentiation and emergence of ccr5(+)cxcl9(+)cxcl10(+) monocyte-derived dendritic cells in the brain during cerebral malaria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097164/
https://www.ncbi.nlm.nih.gov/pubmed/27808089
http://dx.doi.org/10.1038/ncomms13277
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