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Absolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancer

BACKGROUND: To determine whether dose/volume specific endpoints (DVSE) or Area under the rectal DVH curve (rAUC) better predict acute gastrointestinal (GI) toxicity in prostate cancer patients treated with IMRT in the era of daily image guidance (IG-IMRT). METHODS: A set of DVSE was recorded from V2...

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Autores principales: Mirjolet, Céline, Walker, Paul M., Gauthier, Mélanie, Dalban, Cécile, Naudy, Suzanne, Mazoyer, Frédéric, Martin, Etienne, Maingon, Philippe, Créhange, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097436/
https://www.ncbi.nlm.nih.gov/pubmed/27814726
http://dx.doi.org/10.1186/s13014-016-0721-8
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author Mirjolet, Céline
Walker, Paul M.
Gauthier, Mélanie
Dalban, Cécile
Naudy, Suzanne
Mazoyer, Frédéric
Martin, Etienne
Maingon, Philippe
Créhange, Gilles
author_facet Mirjolet, Céline
Walker, Paul M.
Gauthier, Mélanie
Dalban, Cécile
Naudy, Suzanne
Mazoyer, Frédéric
Martin, Etienne
Maingon, Philippe
Créhange, Gilles
author_sort Mirjolet, Céline
collection PubMed
description BACKGROUND: To determine whether dose/volume specific endpoints (DVSE) or Area under the rectal DVH curve (rAUC) better predict acute gastrointestinal (GI) toxicity in prostate cancer patients treated with IMRT in the era of daily image guidance (IG-IMRT). METHODS: A set of DVSE was recorded from V25 to V75 (increments of 5Gy) (both in % and in cc) for 180 men. The rAUC was calculated for doses ranging between 25Gy and 50Gy (rAUC(25–50)). Univariate and multivariate logistic regressions were performed to determine the relationship between DVSE or rAUC(25–50) and the appearance of any acute GI toxicity. RESULTS: The rates of acute grade 1 (G1), G2 and G3 GI toxicities were 53.3 %, 10.6 % and 1.1 %, respectively. No G4+ toxicity was observed. Rectal V25 to V75 expressed in % were not predictive of G ≥ 1 GI toxicity (p ≥ 0.12) whereas rectal V25 to V50 expressed in cc did correlate with GI toxicity G ≥ 1 (p ≤ 0.04). rAUC(25–50) expressed in cc. Gy correlated significantly with the occurrence of any acute GI toxicity G ≥ 1 (p = 0.027). CONCLUSIONS: The absolute volume of the rectum between 25Gy and 50Gy and rAUC(25–50) could significantly predict any acute rectal toxicity in prostate cancer patients treated with daily IG-IMRT.
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spelling pubmed-50974362016-11-08 Absolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancer Mirjolet, Céline Walker, Paul M. Gauthier, Mélanie Dalban, Cécile Naudy, Suzanne Mazoyer, Frédéric Martin, Etienne Maingon, Philippe Créhange, Gilles Radiat Oncol Research BACKGROUND: To determine whether dose/volume specific endpoints (DVSE) or Area under the rectal DVH curve (rAUC) better predict acute gastrointestinal (GI) toxicity in prostate cancer patients treated with IMRT in the era of daily image guidance (IG-IMRT). METHODS: A set of DVSE was recorded from V25 to V75 (increments of 5Gy) (both in % and in cc) for 180 men. The rAUC was calculated for doses ranging between 25Gy and 50Gy (rAUC(25–50)). Univariate and multivariate logistic regressions were performed to determine the relationship between DVSE or rAUC(25–50) and the appearance of any acute GI toxicity. RESULTS: The rates of acute grade 1 (G1), G2 and G3 GI toxicities were 53.3 %, 10.6 % and 1.1 %, respectively. No G4+ toxicity was observed. Rectal V25 to V75 expressed in % were not predictive of G ≥ 1 GI toxicity (p ≥ 0.12) whereas rectal V25 to V50 expressed in cc did correlate with GI toxicity G ≥ 1 (p ≤ 0.04). rAUC(25–50) expressed in cc. Gy correlated significantly with the occurrence of any acute GI toxicity G ≥ 1 (p = 0.027). CONCLUSIONS: The absolute volume of the rectum between 25Gy and 50Gy and rAUC(25–50) could significantly predict any acute rectal toxicity in prostate cancer patients treated with daily IG-IMRT. BioMed Central 2016-11-04 /pmc/articles/PMC5097436/ /pubmed/27814726 http://dx.doi.org/10.1186/s13014-016-0721-8 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Mirjolet, Céline
Walker, Paul M.
Gauthier, Mélanie
Dalban, Cécile
Naudy, Suzanne
Mazoyer, Frédéric
Martin, Etienne
Maingon, Philippe
Créhange, Gilles
Absolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancer
title Absolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancer
title_full Absolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancer
title_fullStr Absolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancer
title_full_unstemmed Absolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancer
title_short Absolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancer
title_sort absolute volume of the rectum and auc from rectal dvh between 25gy and 50gy predict acute gastrointestinal toxicity with ig-imrt in prostate cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097436/
https://www.ncbi.nlm.nih.gov/pubmed/27814726
http://dx.doi.org/10.1186/s13014-016-0721-8
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