Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs

Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures. In this mini review, we will discuss the role of antigen-presenting cells an...

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Detalles Bibliográficos
Autores principales: Hughes, Catherine E., Benson, Robert A., Bedaj, Marija, Maffia, Pasquale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097899/
https://www.ncbi.nlm.nih.gov/pubmed/27872626
http://dx.doi.org/10.3389/fimmu.2016.00481
Descripción
Sumario:Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures. In this mini review, we will discuss the role of antigen-presenting cells and mechanisms of antigen presentation in TLOs, summarizing what is currently known about this facet of the formation and function of these tissues as well as identifying questions yet to be addressed.

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