Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs

Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures. In this mini review, we will discuss the role of antigen-presenting cells an...

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Autores principales: Hughes, Catherine E., Benson, Robert A., Bedaj, Marija, Maffia, Pasquale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097899/
https://www.ncbi.nlm.nih.gov/pubmed/27872626
http://dx.doi.org/10.3389/fimmu.2016.00481
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author Hughes, Catherine E.
Benson, Robert A.
Bedaj, Marija
Maffia, Pasquale
author_facet Hughes, Catherine E.
Benson, Robert A.
Bedaj, Marija
Maffia, Pasquale
author_sort Hughes, Catherine E.
collection PubMed
description Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures. In this mini review, we will discuss the role of antigen-presenting cells and mechanisms of antigen presentation in TLOs, summarizing what is currently known about this facet of the formation and function of these tissues as well as identifying questions yet to be addressed.
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spelling pubmed-50978992016-11-21 Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs Hughes, Catherine E. Benson, Robert A. Bedaj, Marija Maffia, Pasquale Front Immunol Immunology Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures. In this mini review, we will discuss the role of antigen-presenting cells and mechanisms of antigen presentation in TLOs, summarizing what is currently known about this facet of the formation and function of these tissues as well as identifying questions yet to be addressed. Frontiers Media S.A. 2016-11-07 /pmc/articles/PMC5097899/ /pubmed/27872626 http://dx.doi.org/10.3389/fimmu.2016.00481 Text en Copyright © 2016 Hughes, Benson, Bedaj and Maffia. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Hughes, Catherine E.
Benson, Robert A.
Bedaj, Marija
Maffia, Pasquale
Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs
title Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs
title_full Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs
title_fullStr Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs
title_full_unstemmed Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs
title_short Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs
title_sort antigen-presenting cells and antigen presentation in tertiary lymphoid organs
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097899/
https://www.ncbi.nlm.nih.gov/pubmed/27872626
http://dx.doi.org/10.3389/fimmu.2016.00481
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