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Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review
Type II diabetes mellitus is one of the most common public health problems worldwide. Its increasing prevalence in several countries and the difficult metabolic control of individuals with the disease justify studying strategies for primary prevention. The population has sought alternative and cheap...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098081/ https://www.ncbi.nlm.nih.gov/pubmed/27843476 http://dx.doi.org/10.1155/2016/3537163 |
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author | Coelho, Gabriela Diniz Pinto Martins, Vanessa Soares do Amaral, Laura Vieira Novaes, Rômulo Dias Sarandy, Mariáurea Matias Gonçalves, Reggiani Vilela |
author_facet | Coelho, Gabriela Diniz Pinto Martins, Vanessa Soares do Amaral, Laura Vieira Novaes, Rômulo Dias Sarandy, Mariáurea Matias Gonçalves, Reggiani Vilela |
author_sort | Coelho, Gabriela Diniz Pinto |
collection | PubMed |
description | Type II diabetes mellitus is one of the most common public health problems worldwide. Its increasing prevalence in several countries and the difficult metabolic control of individuals with the disease justify studying strategies for primary prevention. The population has sought alternative and cheaper ways to treat the disease, including the use of plants considered medicinal by the population. In this study, we carried out a systematic review on the applicability of isolates and fractions of plant extracts in animal models in type II diabetes. A literature search was performed in MEDLINE/PubMed and Scopus databases. Studies using other experimental animals (horses, rabbits, and monkeys) and humans as well as articles in Chinese, German, and Russian were excluded. We assessed the quality of the studies included by using the criteria described in the ARRIVE guidelines. In general, the animals that received fractions or isolates presented reduced blood glucose levels, normalization of body weight and plasma insulin levels, and reduced total triglycerides and cholesterol. In addition, we observed wide variation among the analyzed parameters, which hindered comparison between the studies found. In further studies, standardized reports and experimental design would help to establish comparable study groups and advance the overall knowledge, thus facilitating translatability from animal data to human clinical conditions. |
format | Online Article Text |
id | pubmed-5098081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-50980812016-11-14 Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review Coelho, Gabriela Diniz Pinto Martins, Vanessa Soares do Amaral, Laura Vieira Novaes, Rômulo Dias Sarandy, Mariáurea Matias Gonçalves, Reggiani Vilela Evid Based Complement Alternat Med Review Article Type II diabetes mellitus is one of the most common public health problems worldwide. Its increasing prevalence in several countries and the difficult metabolic control of individuals with the disease justify studying strategies for primary prevention. The population has sought alternative and cheaper ways to treat the disease, including the use of plants considered medicinal by the population. In this study, we carried out a systematic review on the applicability of isolates and fractions of plant extracts in animal models in type II diabetes. A literature search was performed in MEDLINE/PubMed and Scopus databases. Studies using other experimental animals (horses, rabbits, and monkeys) and humans as well as articles in Chinese, German, and Russian were excluded. We assessed the quality of the studies included by using the criteria described in the ARRIVE guidelines. In general, the animals that received fractions or isolates presented reduced blood glucose levels, normalization of body weight and plasma insulin levels, and reduced total triglycerides and cholesterol. In addition, we observed wide variation among the analyzed parameters, which hindered comparison between the studies found. In further studies, standardized reports and experimental design would help to establish comparable study groups and advance the overall knowledge, thus facilitating translatability from animal data to human clinical conditions. Hindawi Publishing Corporation 2016 2016-10-24 /pmc/articles/PMC5098081/ /pubmed/27843476 http://dx.doi.org/10.1155/2016/3537163 Text en Copyright © 2016 Gabriela Diniz Pinto Coelho et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Coelho, Gabriela Diniz Pinto Martins, Vanessa Soares do Amaral, Laura Vieira Novaes, Rômulo Dias Sarandy, Mariáurea Matias Gonçalves, Reggiani Vilela Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review |
title | Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review |
title_full | Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review |
title_fullStr | Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review |
title_full_unstemmed | Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review |
title_short | Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review |
title_sort | applicability of isolates and fractions of plant extracts in murine models in type ii diabetes: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098081/ https://www.ncbi.nlm.nih.gov/pubmed/27843476 http://dx.doi.org/10.1155/2016/3537163 |
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