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Cystatin C Levels in Middle-Aged Patients with Obstructive Sleep Apnea Syndrome
Background. Obstructive sleep apnea syndrome (OSAS) is associated with systemic inflammation and increased risk of cardiovascular and chronic kidney disease. Cystatin C (Cyst C) is a novel biomarker of both latent renal damage and cardiovascular disease. Aim of the study was to measure serum levels...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098092/ https://www.ncbi.nlm.nih.gov/pubmed/27843647 http://dx.doi.org/10.1155/2016/8081723 |
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author | Archontogeorgis, Kostas Nena, Evangelia Tsigalou, Christina Voulgaris, Athanasios Xanthoudaki, Maria Froudarakis, Marios Steiropoulos, Paschalis |
author_facet | Archontogeorgis, Kostas Nena, Evangelia Tsigalou, Christina Voulgaris, Athanasios Xanthoudaki, Maria Froudarakis, Marios Steiropoulos, Paschalis |
author_sort | Archontogeorgis, Kostas |
collection | PubMed |
description | Background. Obstructive sleep apnea syndrome (OSAS) is associated with systemic inflammation and increased risk of cardiovascular and chronic kidney disease. Cystatin C (Cyst C) is a novel biomarker of both latent renal damage and cardiovascular disease. Aim of the study was to measure serum levels of Cyst C, as well as IL-8 and CRP, in otherwise healthy OSAS patients. Methods. 84 individuals examined with polysomnography for OSAS symptoms without known comorbidities were prospectively recruited. Results. According to apnea hypopnea index (AHI) subjects were divided in two groups: OSAS group (AHI > 5/hour, n = 64) and controls (AHI < 5/hour, n = 20), which were age- and BMI-matched. Cyst C levels were higher in OSAS patients versus controls (1176.13 ± 351.33 versus 938.60 ± 245.83 ng/mL, resp.; p = 0.017) while serum IL-8 and CRP levels did not differ significantly. Positive correlation was found between Cyst C levels and respiratory disturbance index (RDI) (r = 0.240, p = 0.039) and percentage of time with oxygen saturation <90% (r = 0.290, p = 0.02) and negative correlation was found between Cyst C levels and average oxygen saturation during sleep (r = −0.291, p = 0.012). After adjustment for age and BMI, RDI was the only independent predictor of Cyst C levels (β = 0.256, p = 0.039). Conclusion. Cyst C serum levels are increased in OSAS patients without comorbidities, suggesting an increased renal and cardiovascular disease risk. |
format | Online Article Text |
id | pubmed-5098092 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-50980922016-11-14 Cystatin C Levels in Middle-Aged Patients with Obstructive Sleep Apnea Syndrome Archontogeorgis, Kostas Nena, Evangelia Tsigalou, Christina Voulgaris, Athanasios Xanthoudaki, Maria Froudarakis, Marios Steiropoulos, Paschalis Pulm Med Research Article Background. Obstructive sleep apnea syndrome (OSAS) is associated with systemic inflammation and increased risk of cardiovascular and chronic kidney disease. Cystatin C (Cyst C) is a novel biomarker of both latent renal damage and cardiovascular disease. Aim of the study was to measure serum levels of Cyst C, as well as IL-8 and CRP, in otherwise healthy OSAS patients. Methods. 84 individuals examined with polysomnography for OSAS symptoms without known comorbidities were prospectively recruited. Results. According to apnea hypopnea index (AHI) subjects were divided in two groups: OSAS group (AHI > 5/hour, n = 64) and controls (AHI < 5/hour, n = 20), which were age- and BMI-matched. Cyst C levels were higher in OSAS patients versus controls (1176.13 ± 351.33 versus 938.60 ± 245.83 ng/mL, resp.; p = 0.017) while serum IL-8 and CRP levels did not differ significantly. Positive correlation was found between Cyst C levels and respiratory disturbance index (RDI) (r = 0.240, p = 0.039) and percentage of time with oxygen saturation <90% (r = 0.290, p = 0.02) and negative correlation was found between Cyst C levels and average oxygen saturation during sleep (r = −0.291, p = 0.012). After adjustment for age and BMI, RDI was the only independent predictor of Cyst C levels (β = 0.256, p = 0.039). Conclusion. Cyst C serum levels are increased in OSAS patients without comorbidities, suggesting an increased renal and cardiovascular disease risk. Hindawi Publishing Corporation 2016 2016-10-24 /pmc/articles/PMC5098092/ /pubmed/27843647 http://dx.doi.org/10.1155/2016/8081723 Text en Copyright © 2016 Kostas Archontogeorgis et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Archontogeorgis, Kostas Nena, Evangelia Tsigalou, Christina Voulgaris, Athanasios Xanthoudaki, Maria Froudarakis, Marios Steiropoulos, Paschalis Cystatin C Levels in Middle-Aged Patients with Obstructive Sleep Apnea Syndrome |
title | Cystatin C Levels in Middle-Aged Patients with Obstructive Sleep Apnea Syndrome |
title_full | Cystatin C Levels in Middle-Aged Patients with Obstructive Sleep Apnea Syndrome |
title_fullStr | Cystatin C Levels in Middle-Aged Patients with Obstructive Sleep Apnea Syndrome |
title_full_unstemmed | Cystatin C Levels in Middle-Aged Patients with Obstructive Sleep Apnea Syndrome |
title_short | Cystatin C Levels in Middle-Aged Patients with Obstructive Sleep Apnea Syndrome |
title_sort | cystatin c levels in middle-aged patients with obstructive sleep apnea syndrome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098092/ https://www.ncbi.nlm.nih.gov/pubmed/27843647 http://dx.doi.org/10.1155/2016/8081723 |
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