Cargando…

An Acetamide Derivative as a Camptothecin Sensitizer for Human Non-Small-Cell Lung Cancer Cells through Increased Oxidative Stress and JNK Activation

In recent years, combination chemotherapy is a primary strategy for treating lung cancer; however, the issues of antagonism and side effects still limit its applications. The development of chemosensitizer aims to sensitize chemoresistant cancer cells to anticancer drugs and therefore improve the ef...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chou, Han-Lin, Fong, Yao, Lin, Hsin-Hsien, Tsai, Eing Mei, Chen, Jeff Yi-Fu, Chang, Wen-Tsan, Wu, Chang-Yi, David Wang, Hui-Min, Huang, Hurng-Wern, Chiu, Chien-Chih
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098095/ https://www.ncbi.nlm.nih.gov/pubmed/27843533 http://dx.doi.org/10.1155/2016/9128102

Ejemplares similares

Human non-small cell lung cancer cells can be sensitized to camptothecin by modulating autophagy
por: Chiu, Yi-Han, et al.
Publicado: (2018)

The antiproliferative effect of C(2)-ceramide on lung cancer cells through apoptosis by inhibiting Akt and NFκB
por: Lin, I-Ling, et al.
Publicado: (2014)

Combination Therapy of Chloroquine and C(2)-Ceramide Enhances Cytotoxicity in Lung Cancer H460 and H1299 Cells
por: Chou, Han-Lin, et al.
Publicado: (2019)

Exogenous C(8)-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells
por: Chang, Yuli C., et al.
Publicado: (2018)

Activation of SAPK/JNK by camptothecin sensitizes androgen-independent prostate cancer cells to Fas-induced apoptosis
por: Costa-Pereira, A P, et al.
Publicado: (2000)

The Phenoxyphenol Compound 4-HPPP Selectively Induces Antiproliferation Effects and Apoptosis in Human Lung Cancer Cells through Aneupolyploidization and ATR DNA Repair Signaling
por: Liu, Wangta, et al.
Publicado: (2020)

Protective Effect of Caffeic Acid on Paclitaxel Induced Anti-Proliferation and Apoptosis of Lung Cancer Cells Involves NF-κB Pathway
por: Lin, Chien-Liang, et al.
Publicado: (2012)

Synthesis, Experimental and Density Functional Theory (DFT) Studies on Solubility of Camptothecin Derivatives
por: Lai, Chin-Hung, et al.
Publicado: (2018)

BPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model
por: Chiu, Chien-Chih, et al.
Publicado: (2015)

The Long-Term DEHP Exposure Confers Multidrug Resistance of Triple-Negative Breast Cancer Cells through ABC Transporters and Intracellular ROS
por: Jadhao, Mahendra, et al.
Publicado: (2021)

BubR1 Acts as a Promoter in Cellular Motility of Human Oral Squamous Cancer Cells through Regulating MMP-2 and MMP-9
por: Chou, Chou-Kit, et al.
Publicado: (2015)

The Melanogenesis Alteration Effects of Achillea millefolium L. Essential Oil and Linalyl Acetate: Involvement of Oxidative Stress and the JNK and ERK Signaling Pathways in Melanoma Cells
por: Peng, Hsin-Yi, et al.
Publicado: (2014)

The Role of Nonapoptotic Programmed Cell Death — Ferroptosis, Necroptosis, and Pyroptosis — in Pancreatic Ductal Adenocarcinoma Treatment
por: Hsu, Sheng-Kai, et al.
Publicado: (2022)

Golden Berry-Derived 4β-hydroxywithanolide E for Selectively Killing Oral Cancer Cells by Generating ROS, DNA Damage, and Apoptotic Pathways
por: Chiu, Chien-Chih, et al.
Publicado: (2013)

Effects of the combination of camptothecin and doxorubicin or etoposide on rat glioma cells and camptothecin-resistant variants
por: Pavillard, V, et al.
Publicado: (2001)

IL‐10 from plasmacytoid dendritic cells promotes angiogenesis in the early stage of endometriosis
por: Suen, Jau‐Ling, et al.
Publicado: (2019)

Direct Binding of Cisplatin to p22phox, an Endoplasmic Reticulum (ER) Membrane Protein, Contributes to Cisplatin Resistance in Oral Squamous Cell Carcinoma (OSCC) Cells
por: Hung, Chih-Chang, et al.
Publicado: (2020)

Chromatin determinants impart camptothecin sensitivity
por: Puddu, Fabio, et al.
Publicado: (2017)

C(2)-Ceramide-Induced Rb-Dominant Senescence-Like Phenotype Leads to Human Breast Cancer MCF-7 Escape from p53-Dependent Cell Death
por: Chang, Wen-Tsan, et al.
Publicado: (2019)

HO-3867 Induces Apoptosis via the JNK Signaling Pathway in Human Osteosarcoma Cells
por: Lu, Peace Wun-Ang, et al.
Publicado: (2022)

Oxidative Stress-Dependent Synergistic Antiproliferation, Apoptosis, and DNA Damage of Ultraviolet-C and Coral-Derived Sinularin Combined Treatment for Oral Cancer Cells
por: Peng, Sheng-Yao, et al.
Publicado: (2021)

Endoglin Modulates TGFβR2 Induced VEGF and Proinflammatory Cytokine Axis Mediated Angiogenesis in Prolonged DEHP-Exposed Breast Cancer Cells
por: Jadhao, Mahendra, et al.
Publicado: (2022)

A novel cell-penetrating peptide suppresses breast tumorigenesis by inhibiting β-catenin/LEF-1 signaling
por: Hsieh, Tsung-Hua, et al.
Publicado: (2016)

diTFPP, a Phenoxyphenol, Sensitizes Hepatocellular Carcinoma Cells to C(2)-Ceramide-Induced Autophagic Stress by Increasing Oxidative Stress and ER Stress Accompanied by LAMP2 Hypoglycosylation
por: Chiu, Chien-Chih, et al.
Publicado: (2022)

A Thrombomodulin Gene Polymorphism (C1418T) Is Associated with Early Outcomes in Patients Undergoing Coronary Artery Bypass Graft Surgery with a Conventional Cardiopulmonary Bypass during Hospitalization
por: Pai, Ching-Chou, et al.
Publicado: (2017)

Transcriptome Profiling of Eutopic and Ectopic Endometrial Stromal Cells in Women with Endometriosis Based on High-Throughput Sequencing
por: Chen, Chih-Chieh, et al.
Publicado: (2022)

Preclinical effects of CRLX101, an investigational camptothecin-containing nanoparticle drug conjugate, on treating glioblastoma multiforme via apoptosis and antiangiogenesis
por: Lin, Chien-Ju, et al.
Publicado: (2016)

Syk/JNK/AP-1 Signaling Pathway Mediates Interleukin-6-Promoted Cell Migration in Oral Squamous Cell Carcinoma
por: Chuang, Jing-Yuan, et al.
Publicado: (2014)

Targeting of Topoisomerase I for Prognoses and Therapeutics of Camptothecin-Resistant Ovarian Cancer
por: Lee, Yu-Chieh, et al.
Publicado: (2015)

Design, Synthesis, Mechanisms of Action, and Toxicity of Novel 20(S)-Sulfonylamidine Derivatives of Camptothecin as Potent Antitumor Agents
por: Wang, Mei-Juan, et al.
Publicado: (2014)

Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity
por: Wu, Ming-Yue, et al.
Publicado: (2017)

Dehydrocrenatidine Induces Liver Cancer Cell Apoptosis by Suppressing JNK-Mediated Signaling
por: Velmurugan, Bharath Kumar, et al.
Publicado: (2022)

Host immune response to anti-cancer camptothecin conjugated cyclodextrin-based polymers
por: Chen, Yi-Fan, et al.
Publicado: (2019)

Camptothecin improves sorafenib sensitivity by inhibiting Nrf2‑ARE pathway in hepatocellular carcinoma
por: Sun, Liwei, et al.
Publicado: (2023)

Characterization of DNA Topoisomerase-1 in Spodoptera exigua for Toxicity Evaluation of Camptothecin and Hydoxy-Camptothecin
por: Zhang, Lan, et al.
Publicado: (2013)

Dehydrocrenatidine extracted from Picrasma quassioides induces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways
por: Hsieh, Ming-Chang, et al.
Publicado: (2021)

Visceral obesity and cell cycle pathways serve as links in the association between bisphenol A exposure and breast cancer
por: Wang, Tsu-Nai, et al.
Publicado: (2020)

The Phenoxyphenol Compound diTFPP Mediates Exogenous C(2)-Ceramide Metabolism, Inducing Cell Apoptosis Accompanied by ROS Formation and Autophagy in Hepatocellular Carcinoma Cells
por: Chang, Wen-Tsan, et al.
Publicado: (2021)

CCL3 promotes angiogenesis by dysregulation of miR-374b/ VEGF-A axis in human osteosarcoma cells
por: Liao, Yuan-Ya, et al.
Publicado: (2015)

Visfatin Promotes IL-6 and TNF-α Production in Human Synovial Fibroblasts by Repressing miR-199a-5p through ERK, p38 and JNK Signaling Pathways
por: Wu, Min-Huan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ju3l5si2o8v69b90c49ti3cmpe