Cargando…

Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology

Deficiency of vitamin D is associated with increased risk of several types of cancer including colorectal cancer (CRC). However, factors contributing to low levels of 25-hydroxyvitamin D [25(OH)D] in CRC are not clear. Therefore, in this study serum 25(OH)D levels in 117 CRC patients and 86 controls...

Descripción completa

Detalles Bibliográficos
Autores principales: Väyrynen, Juha P., Mutt, Shivaprakash J., Herzig, Karl-Heinz, Väyrynen, Sara A., Kantola, Tiina, Karhu, Toni, Karttunen, Tuomo J., Klintrup, Kai, Mäkelä, Jyrki, Mäkinen, Markus J., Tuomisto, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098144/
https://www.ncbi.nlm.nih.gov/pubmed/27819306
http://dx.doi.org/10.1038/srep36519
_version_ 1782465725878763520
author Väyrynen, Juha P.
Mutt, Shivaprakash J.
Herzig, Karl-Heinz
Väyrynen, Sara A.
Kantola, Tiina
Karhu, Toni
Karttunen, Tuomo J.
Klintrup, Kai
Mäkelä, Jyrki
Mäkinen, Markus J.
Tuomisto, Anne
author_facet Väyrynen, Juha P.
Mutt, Shivaprakash J.
Herzig, Karl-Heinz
Väyrynen, Sara A.
Kantola, Tiina
Karhu, Toni
Karttunen, Tuomo J.
Klintrup, Kai
Mäkelä, Jyrki
Mäkinen, Markus J.
Tuomisto, Anne
author_sort Väyrynen, Juha P.
collection PubMed
description Deficiency of vitamin D is associated with increased risk of several types of cancer including colorectal cancer (CRC). However, factors contributing to low levels of 25-hydroxyvitamin D [25(OH)D] in CRC are not clear. Therefore, in this study serum 25(OH)D levels in 117 CRC patients and 86 controls were analyzed and correlated with the clinicopathological data including morphological subtype (serrated or conventional), quantity of tumor infiltrating immune cells, levels of systemic inflammatory markers, and disease outcome. We found that the patients had lower serum 25(OH)D levels compared to the controls. Interestingly, among the patients mismatch repair deficiency, serrated morphology, and high body mass index associated with lowest serum 25(OH)D levels. In addition, patients operated in summer or autumn had higher serum 25(OH)D levels. Furthermore, serum 25(OH)D levels inversely correlated with several systemic inflammatory markers, e.g. serum C reactive protein, but did not associate with prognosis. Mechanism leading to vitamin D deficiency in these patients are not clear but could be related to the effects of systemic inflammation. Longitudinal studies are warranted to assess vitamin D deficiency as a potential risk factor for serrated colorectal polyps and adenocarcinoma.
format Online
Article
Text
id pubmed-5098144
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-50981442016-11-10 Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology Väyrynen, Juha P. Mutt, Shivaprakash J. Herzig, Karl-Heinz Väyrynen, Sara A. Kantola, Tiina Karhu, Toni Karttunen, Tuomo J. Klintrup, Kai Mäkelä, Jyrki Mäkinen, Markus J. Tuomisto, Anne Sci Rep Article Deficiency of vitamin D is associated with increased risk of several types of cancer including colorectal cancer (CRC). However, factors contributing to low levels of 25-hydroxyvitamin D [25(OH)D] in CRC are not clear. Therefore, in this study serum 25(OH)D levels in 117 CRC patients and 86 controls were analyzed and correlated with the clinicopathological data including morphological subtype (serrated or conventional), quantity of tumor infiltrating immune cells, levels of systemic inflammatory markers, and disease outcome. We found that the patients had lower serum 25(OH)D levels compared to the controls. Interestingly, among the patients mismatch repair deficiency, serrated morphology, and high body mass index associated with lowest serum 25(OH)D levels. In addition, patients operated in summer or autumn had higher serum 25(OH)D levels. Furthermore, serum 25(OH)D levels inversely correlated with several systemic inflammatory markers, e.g. serum C reactive protein, but did not associate with prognosis. Mechanism leading to vitamin D deficiency in these patients are not clear but could be related to the effects of systemic inflammation. Longitudinal studies are warranted to assess vitamin D deficiency as a potential risk factor for serrated colorectal polyps and adenocarcinoma. Nature Publishing Group 2016-11-07 /pmc/articles/PMC5098144/ /pubmed/27819306 http://dx.doi.org/10.1038/srep36519 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Väyrynen, Juha P.
Mutt, Shivaprakash J.
Herzig, Karl-Heinz
Väyrynen, Sara A.
Kantola, Tiina
Karhu, Toni
Karttunen, Tuomo J.
Klintrup, Kai
Mäkelä, Jyrki
Mäkinen, Markus J.
Tuomisto, Anne
Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology
title Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology
title_full Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology
title_fullStr Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology
title_full_unstemmed Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology
title_short Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology
title_sort decreased preoperative serum 25-hydroxyvitamin d levels in colorectal cancer are associated with systemic inflammation and serrated morphology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098144/
https://www.ncbi.nlm.nih.gov/pubmed/27819306
http://dx.doi.org/10.1038/srep36519
work_keys_str_mv AT vayrynenjuhap decreasedpreoperativeserum25hydroxyvitamindlevelsincolorectalcancerareassociatedwithsystemicinflammationandserratedmorphology
AT muttshivaprakashj decreasedpreoperativeserum25hydroxyvitamindlevelsincolorectalcancerareassociatedwithsystemicinflammationandserratedmorphology
AT herzigkarlheinz decreasedpreoperativeserum25hydroxyvitamindlevelsincolorectalcancerareassociatedwithsystemicinflammationandserratedmorphology
AT vayrynensaraa decreasedpreoperativeserum25hydroxyvitamindlevelsincolorectalcancerareassociatedwithsystemicinflammationandserratedmorphology
AT kantolatiina decreasedpreoperativeserum25hydroxyvitamindlevelsincolorectalcancerareassociatedwithsystemicinflammationandserratedmorphology
AT karhutoni decreasedpreoperativeserum25hydroxyvitamindlevelsincolorectalcancerareassociatedwithsystemicinflammationandserratedmorphology
AT karttunentuomoj decreasedpreoperativeserum25hydroxyvitamindlevelsincolorectalcancerareassociatedwithsystemicinflammationandserratedmorphology
AT klintrupkai decreasedpreoperativeserum25hydroxyvitamindlevelsincolorectalcancerareassociatedwithsystemicinflammationandserratedmorphology
AT makelajyrki decreasedpreoperativeserum25hydroxyvitamindlevelsincolorectalcancerareassociatedwithsystemicinflammationandserratedmorphology
AT makinenmarkusj decreasedpreoperativeserum25hydroxyvitamindlevelsincolorectalcancerareassociatedwithsystemicinflammationandserratedmorphology
AT tuomistoanne decreasedpreoperativeserum25hydroxyvitamindlevelsincolorectalcancerareassociatedwithsystemicinflammationandserratedmorphology