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Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology
Deficiency of vitamin D is associated with increased risk of several types of cancer including colorectal cancer (CRC). However, factors contributing to low levels of 25-hydroxyvitamin D [25(OH)D] in CRC are not clear. Therefore, in this study serum 25(OH)D levels in 117 CRC patients and 86 controls...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098144/ https://www.ncbi.nlm.nih.gov/pubmed/27819306 http://dx.doi.org/10.1038/srep36519 |
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author | Väyrynen, Juha P. Mutt, Shivaprakash J. Herzig, Karl-Heinz Väyrynen, Sara A. Kantola, Tiina Karhu, Toni Karttunen, Tuomo J. Klintrup, Kai Mäkelä, Jyrki Mäkinen, Markus J. Tuomisto, Anne |
author_facet | Väyrynen, Juha P. Mutt, Shivaprakash J. Herzig, Karl-Heinz Väyrynen, Sara A. Kantola, Tiina Karhu, Toni Karttunen, Tuomo J. Klintrup, Kai Mäkelä, Jyrki Mäkinen, Markus J. Tuomisto, Anne |
author_sort | Väyrynen, Juha P. |
collection | PubMed |
description | Deficiency of vitamin D is associated with increased risk of several types of cancer including colorectal cancer (CRC). However, factors contributing to low levels of 25-hydroxyvitamin D [25(OH)D] in CRC are not clear. Therefore, in this study serum 25(OH)D levels in 117 CRC patients and 86 controls were analyzed and correlated with the clinicopathological data including morphological subtype (serrated or conventional), quantity of tumor infiltrating immune cells, levels of systemic inflammatory markers, and disease outcome. We found that the patients had lower serum 25(OH)D levels compared to the controls. Interestingly, among the patients mismatch repair deficiency, serrated morphology, and high body mass index associated with lowest serum 25(OH)D levels. In addition, patients operated in summer or autumn had higher serum 25(OH)D levels. Furthermore, serum 25(OH)D levels inversely correlated with several systemic inflammatory markers, e.g. serum C reactive protein, but did not associate with prognosis. Mechanism leading to vitamin D deficiency in these patients are not clear but could be related to the effects of systemic inflammation. Longitudinal studies are warranted to assess vitamin D deficiency as a potential risk factor for serrated colorectal polyps and adenocarcinoma. |
format | Online Article Text |
id | pubmed-5098144 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50981442016-11-10 Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology Väyrynen, Juha P. Mutt, Shivaprakash J. Herzig, Karl-Heinz Väyrynen, Sara A. Kantola, Tiina Karhu, Toni Karttunen, Tuomo J. Klintrup, Kai Mäkelä, Jyrki Mäkinen, Markus J. Tuomisto, Anne Sci Rep Article Deficiency of vitamin D is associated with increased risk of several types of cancer including colorectal cancer (CRC). However, factors contributing to low levels of 25-hydroxyvitamin D [25(OH)D] in CRC are not clear. Therefore, in this study serum 25(OH)D levels in 117 CRC patients and 86 controls were analyzed and correlated with the clinicopathological data including morphological subtype (serrated or conventional), quantity of tumor infiltrating immune cells, levels of systemic inflammatory markers, and disease outcome. We found that the patients had lower serum 25(OH)D levels compared to the controls. Interestingly, among the patients mismatch repair deficiency, serrated morphology, and high body mass index associated with lowest serum 25(OH)D levels. In addition, patients operated in summer or autumn had higher serum 25(OH)D levels. Furthermore, serum 25(OH)D levels inversely correlated with several systemic inflammatory markers, e.g. serum C reactive protein, but did not associate with prognosis. Mechanism leading to vitamin D deficiency in these patients are not clear but could be related to the effects of systemic inflammation. Longitudinal studies are warranted to assess vitamin D deficiency as a potential risk factor for serrated colorectal polyps and adenocarcinoma. Nature Publishing Group 2016-11-07 /pmc/articles/PMC5098144/ /pubmed/27819306 http://dx.doi.org/10.1038/srep36519 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Väyrynen, Juha P. Mutt, Shivaprakash J. Herzig, Karl-Heinz Väyrynen, Sara A. Kantola, Tiina Karhu, Toni Karttunen, Tuomo J. Klintrup, Kai Mäkelä, Jyrki Mäkinen, Markus J. Tuomisto, Anne Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology |
title | Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology |
title_full | Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology |
title_fullStr | Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology |
title_full_unstemmed | Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology |
title_short | Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology |
title_sort | decreased preoperative serum 25-hydroxyvitamin d levels in colorectal cancer are associated with systemic inflammation and serrated morphology |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098144/ https://www.ncbi.nlm.nih.gov/pubmed/27819306 http://dx.doi.org/10.1038/srep36519 |
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