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Minicircle HBV cccDNA with a Gaussia luciferase reporter for investigating HBV cccDNA biology and developing cccDNA-targeting drugs

Chronic Hepatitis B Virus (HBV) infection is generally not curable with current anti-viral drugs. Virus rebounds after stopping treatment from the stable HBV covalently-closed-circular DNA (cccDNA). The development of drugs that directly target cccDNA is hampered by the lack of robust HBV cccDNA mod...

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Detalles Bibliográficos
Autores principales:	Li, Feng, Cheng, Liang, Murphy, Christopher M., Reszka-Blanco, Natalia J., Wu, Yaxu, Chi, Liqun, Hu, Jianming, Su, Lishan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098228/ https://www.ncbi.nlm.nih.gov/pubmed/27819342 http://dx.doi.org/10.1038/srep36483

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