The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair

Fanconi anemia (FA) is a genetic disease characterized by bone marrow failure and increased cancer risk. The FA proteins function primarily in DNA interstrand crosslink (ICL) repair. Here, we have examined the role of the PTEN phosphatase in this process. We have established that PTEN-deficient cell...

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Detalles Bibliográficos
Autores principales: Vuono, Elizabeth A., Mukherjee, Ananda, Vierra, David A., Adroved, Morganne M., Hodson, Charlotte, Deans, Andrew J., Howlett, Niall G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098254/
https://www.ncbi.nlm.nih.gov/pubmed/27819275
http://dx.doi.org/10.1038/srep36439

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