Expression of CALR mutants causes mpl-dependent thrombocytosis in zebrafish

CALR mutations are identified in about 30% of JAK2/MPL-unmutated myeloproliferative neoplasms (MPNs) including essential thrombocythemia (ET) and primary myelofibrosis. Although the molecular pathogenesis of CALR mutations leading to MPNs has been studied using in vitro cell lines models, how mutant...

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Detalles Bibliográficos
Autores principales: Lim, K-H, Chang, Y-C, Chiang, Y-H, Lin, H-C, Chang, C-Y, Lin, C-S, Huang, L, Wang, W-T, Gon-Shen Chen, C, Chou, W-C, Kuo, Y-Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098260/
https://www.ncbi.nlm.nih.gov/pubmed/27716741
http://dx.doi.org/10.1038/bcj.2016.83

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