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Bartonella Endocarditis and Pauci-Immune Glomerulonephritis: A Case Report and Review of the Literature
Among culture-negative endocarditis in the United States, Bartonella species are the most common cause, with Bartonella henselae and Bartonella quintana comprising the majority of cases. Kidney manifestations, particularly glomerulonephritis, are common sequelae of infectious endocarditis, with near...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098464/ https://www.ncbi.nlm.nih.gov/pubmed/27885316 http://dx.doi.org/10.1097/IPC.0000000000000384 |
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author | Raybould, Jillian E. Raybould, Alison L. Morales, Megan K. Zaheer, Misbah Lipkowitz, Michael S. Timpone, Joseph G. Kumar, Princy N. |
author_facet | Raybould, Jillian E. Raybould, Alison L. Morales, Megan K. Zaheer, Misbah Lipkowitz, Michael S. Timpone, Joseph G. Kumar, Princy N. |
author_sort | Raybould, Jillian E. |
collection | PubMed |
description | Among culture-negative endocarditis in the United States, Bartonella species are the most common cause, with Bartonella henselae and Bartonella quintana comprising the majority of cases. Kidney manifestations, particularly glomerulonephritis, are common sequelae of infectious endocarditis, with nearly half of all Bartonella patients demonstrating renal involvement. Although a pauci-immune pattern is a frequent finding in infectious endocarditis–associated glomerulonephritis, it is rarely reported in Bartonella endocarditis. Anti–neutrophil cytoplasmic antibody (ANCA) positivity can be seen with many pathogens causing endocarditis and has been previously reported with Bartonella species. In addition, ANCA-associated vasculitis can also present with renal and cardiac involvement, including noninfectious valvular vegetations and pauci-immune glomerulonephritis. Given the overlap in their clinical presentation, it is difficult to differentiate between Bartonella endocarditis and ANCA-associated vasculitis but imperative to do so to guide management decisions. We present a case of ANCA-positive Bartonella endocarditis with associated pauci-immune glomerulonephritis that was successfully treated with medical management alone. |
format | Online Article Text |
id | pubmed-5098464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-50984642016-11-22 Bartonella Endocarditis and Pauci-Immune Glomerulonephritis: A Case Report and Review of the Literature Raybould, Jillian E. Raybould, Alison L. Morales, Megan K. Zaheer, Misbah Lipkowitz, Michael S. Timpone, Joseph G. Kumar, Princy N. Infect Dis Clin Pract (Baltim Md) Review Articles Among culture-negative endocarditis in the United States, Bartonella species are the most common cause, with Bartonella henselae and Bartonella quintana comprising the majority of cases. Kidney manifestations, particularly glomerulonephritis, are common sequelae of infectious endocarditis, with nearly half of all Bartonella patients demonstrating renal involvement. Although a pauci-immune pattern is a frequent finding in infectious endocarditis–associated glomerulonephritis, it is rarely reported in Bartonella endocarditis. Anti–neutrophil cytoplasmic antibody (ANCA) positivity can be seen with many pathogens causing endocarditis and has been previously reported with Bartonella species. In addition, ANCA-associated vasculitis can also present with renal and cardiac involvement, including noninfectious valvular vegetations and pauci-immune glomerulonephritis. Given the overlap in their clinical presentation, it is difficult to differentiate between Bartonella endocarditis and ANCA-associated vasculitis but imperative to do so to guide management decisions. We present a case of ANCA-positive Bartonella endocarditis with associated pauci-immune glomerulonephritis that was successfully treated with medical management alone. Lippincott Williams & Wilkins 2016-09 2016-03-01 /pmc/articles/PMC5098464/ /pubmed/27885316 http://dx.doi.org/10.1097/IPC.0000000000000384 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. |
spellingShingle | Review Articles Raybould, Jillian E. Raybould, Alison L. Morales, Megan K. Zaheer, Misbah Lipkowitz, Michael S. Timpone, Joseph G. Kumar, Princy N. Bartonella Endocarditis and Pauci-Immune Glomerulonephritis: A Case Report and Review of the Literature |
title | Bartonella Endocarditis and Pauci-Immune Glomerulonephritis: A Case Report and Review of the Literature |
title_full | Bartonella Endocarditis and Pauci-Immune Glomerulonephritis: A Case Report and Review of the Literature |
title_fullStr | Bartonella Endocarditis and Pauci-Immune Glomerulonephritis: A Case Report and Review of the Literature |
title_full_unstemmed | Bartonella Endocarditis and Pauci-Immune Glomerulonephritis: A Case Report and Review of the Literature |
title_short | Bartonella Endocarditis and Pauci-Immune Glomerulonephritis: A Case Report and Review of the Literature |
title_sort | bartonella endocarditis and pauci-immune glomerulonephritis: a case report and review of the literature |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098464/ https://www.ncbi.nlm.nih.gov/pubmed/27885316 http://dx.doi.org/10.1097/IPC.0000000000000384 |
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