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Dietary vitamin C intake protects against COPD: the Korea National Health and Nutrition Examination Survey in 2012

BACKGROUND: Vitamin C, as an antioxidant, has recently been suggested to provide protection against COPD; however, only few national cohort studies have investigated these effects. We aimed to confirm the protective effects of vitamin C against COPD in Korean patients. PATIENTS AND METHODS: We analy...

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Autores principales: Park, Hye Jung, Byun, Min Kwang, Kim, Hyung Jung, Kim, Jae Yeol, Kim, Yu-Il, Yoo, Kwang-Ha, Chun, Eun Mi, Jung, Ji Ye, Lee, Sang Haak, Ahn, Chul Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098518/
https://www.ncbi.nlm.nih.gov/pubmed/27843308
http://dx.doi.org/10.2147/COPD.S119448
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author Park, Hye Jung
Byun, Min Kwang
Kim, Hyung Jung
Kim, Jae Yeol
Kim, Yu-Il
Yoo, Kwang-Ha
Chun, Eun Mi
Jung, Ji Ye
Lee, Sang Haak
Ahn, Chul Min
author_facet Park, Hye Jung
Byun, Min Kwang
Kim, Hyung Jung
Kim, Jae Yeol
Kim, Yu-Il
Yoo, Kwang-Ha
Chun, Eun Mi
Jung, Ji Ye
Lee, Sang Haak
Ahn, Chul Min
author_sort Park, Hye Jung
collection PubMed
description BACKGROUND: Vitamin C, as an antioxidant, has recently been suggested to provide protection against COPD; however, only few national cohort studies have investigated these effects. We aimed to confirm the protective effects of vitamin C against COPD in Korean patients. PATIENTS AND METHODS: We analyzed the data of 3,283 adults aged ≥40 years (representing 23,541,704 subjects) who underwent pulmonary function tests and responded to questionnaires on smoking history and vitamin C intake, with stratification variables and sampling weight designated by the Korea 2012 National Health and Nutrition Examination Survey. RESULTS: Among all the subjects, 512 (representing 3,459,679 subjects; 15.6%) were diagnosed as having COPD based on pulmonary function test results. Male gender, old age, residence in suburban/rural regions, low household income, low educational level, an occupation in agriculture or fisheries, and heavy smoking were significantly associated with COPD. Low intake of nutrients, including potassium, vitamin A, carotene, retinol, and vitamin C, was significantly associated with COPD. The prevalence of COPD in heavy smokers with the lowest quartile (Q1, <48.50 mg; 63.0%) and low-middle quartile (Q2, 48.50−84.38 mg; 56.4%) of vitamin C intake was significantly higher than that in subjects with the high-middle quartile (Q3, 84.38−141.63 mg; 29.5%) and highest quartile (Q4, >141.63 mg; 32.6%) of vitamin C intake (P=0.015). In multivariate analysis, male gender, old age, heavy smoking, and a low intake of vitamin C were significant independent risk factors for COPD. A significant reduction of 76.7% in COPD risk was observed with a Q3 vitamin C intake compared to Q1 vitamin C intake (odds ratio, 0.233; 95% confidence interval, 0.094−0.576) in heavy smokers. CONCLUSION: This large-scale national study suggests that dietary vitamin C provides protection against COPD, independent of smoking history, in the general Korean population.
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spelling pubmed-50985182016-11-14 Dietary vitamin C intake protects against COPD: the Korea National Health and Nutrition Examination Survey in 2012 Park, Hye Jung Byun, Min Kwang Kim, Hyung Jung Kim, Jae Yeol Kim, Yu-Il Yoo, Kwang-Ha Chun, Eun Mi Jung, Ji Ye Lee, Sang Haak Ahn, Chul Min Int J Chron Obstruct Pulmon Dis Original Research BACKGROUND: Vitamin C, as an antioxidant, has recently been suggested to provide protection against COPD; however, only few national cohort studies have investigated these effects. We aimed to confirm the protective effects of vitamin C against COPD in Korean patients. PATIENTS AND METHODS: We analyzed the data of 3,283 adults aged ≥40 years (representing 23,541,704 subjects) who underwent pulmonary function tests and responded to questionnaires on smoking history and vitamin C intake, with stratification variables and sampling weight designated by the Korea 2012 National Health and Nutrition Examination Survey. RESULTS: Among all the subjects, 512 (representing 3,459,679 subjects; 15.6%) were diagnosed as having COPD based on pulmonary function test results. Male gender, old age, residence in suburban/rural regions, low household income, low educational level, an occupation in agriculture or fisheries, and heavy smoking were significantly associated with COPD. Low intake of nutrients, including potassium, vitamin A, carotene, retinol, and vitamin C, was significantly associated with COPD. The prevalence of COPD in heavy smokers with the lowest quartile (Q1, <48.50 mg; 63.0%) and low-middle quartile (Q2, 48.50−84.38 mg; 56.4%) of vitamin C intake was significantly higher than that in subjects with the high-middle quartile (Q3, 84.38−141.63 mg; 29.5%) and highest quartile (Q4, >141.63 mg; 32.6%) of vitamin C intake (P=0.015). In multivariate analysis, male gender, old age, heavy smoking, and a low intake of vitamin C were significant independent risk factors for COPD. A significant reduction of 76.7% in COPD risk was observed with a Q3 vitamin C intake compared to Q1 vitamin C intake (odds ratio, 0.233; 95% confidence interval, 0.094−0.576) in heavy smokers. CONCLUSION: This large-scale national study suggests that dietary vitamin C provides protection against COPD, independent of smoking history, in the general Korean population. Dove Medical Press 2016-10-31 /pmc/articles/PMC5098518/ /pubmed/27843308 http://dx.doi.org/10.2147/COPD.S119448 Text en © 2016 Park et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Park, Hye Jung
Byun, Min Kwang
Kim, Hyung Jung
Kim, Jae Yeol
Kim, Yu-Il
Yoo, Kwang-Ha
Chun, Eun Mi
Jung, Ji Ye
Lee, Sang Haak
Ahn, Chul Min
Dietary vitamin C intake protects against COPD: the Korea National Health and Nutrition Examination Survey in 2012
title Dietary vitamin C intake protects against COPD: the Korea National Health and Nutrition Examination Survey in 2012
title_full Dietary vitamin C intake protects against COPD: the Korea National Health and Nutrition Examination Survey in 2012
title_fullStr Dietary vitamin C intake protects against COPD: the Korea National Health and Nutrition Examination Survey in 2012
title_full_unstemmed Dietary vitamin C intake protects against COPD: the Korea National Health and Nutrition Examination Survey in 2012
title_short Dietary vitamin C intake protects against COPD: the Korea National Health and Nutrition Examination Survey in 2012
title_sort dietary vitamin c intake protects against copd: the korea national health and nutrition examination survey in 2012
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098518/
https://www.ncbi.nlm.nih.gov/pubmed/27843308
http://dx.doi.org/10.2147/COPD.S119448
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