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The expression of HoxB5 and SPC in neonatal rat lung after exposure to fluoxetine

OBJECTIVE: Approximately 10% of pregnant women suffer from pregnancy-associated depression. Fluoxetine, as a selective serotonin reuptake inhibitor, is being employed as a therapy for depressive disorders. The present study aimed to determine the effects of fluoxetine on neonatal lung development. M...

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Autores principales: Taghizadeh, Razieh, Taghipour, Zahra, Karimi, Akbar, Shamsizadeh, Ali, Taghavi, Mohammad Mohsen, Shariati, Mahdi, Shabanizadeh, Ahmad, Jafari Naveh, Hamid Reza, Bidaki, Reza, Aminzadeh, Fariba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098522/
https://www.ncbi.nlm.nih.gov/pubmed/27843293
http://dx.doi.org/10.2147/DDDT.S109473
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author Taghizadeh, Razieh
Taghipour, Zahra
Karimi, Akbar
Shamsizadeh, Ali
Taghavi, Mohammad Mohsen
Shariati, Mahdi
Shabanizadeh, Ahmad
Jafari Naveh, Hamid Reza
Bidaki, Reza
Aminzadeh, Fariba
author_facet Taghizadeh, Razieh
Taghipour, Zahra
Karimi, Akbar
Shamsizadeh, Ali
Taghavi, Mohammad Mohsen
Shariati, Mahdi
Shabanizadeh, Ahmad
Jafari Naveh, Hamid Reza
Bidaki, Reza
Aminzadeh, Fariba
author_sort Taghizadeh, Razieh
collection PubMed
description OBJECTIVE: Approximately 10% of pregnant women suffer from pregnancy-associated depression. Fluoxetine, as a selective serotonin reuptake inhibitor, is being employed as a therapy for depressive disorders. The present study aimed to determine the effects of fluoxetine on neonatal lung development. METHODS: Thirty pregnant Wistar rats (weighing 200–250 g) were treated daily with 7 mg/kg fluoxetine from gestation day 0 to gestation day 21, via gavage. The control group received a similar volume of distilled water only. Following delivery, the newborns and their lungs were immediately weighed in both of the groups. The right lung was fixed for histological assessments while the left lung was used for evaluation of the expression of SPC and HoxB5 by the real-time polymerase chain reaction method. RESULTS: Results have indicated that even though the body weight and the number of neonatal rats in both groups were the same, the lung weight of neonates exposed to fluoxetine was significantly different compared to the control group (P<0.05). Expression of both genes was increased, nonetheless, only elevation of HoxB5 was significant (P<0.05). Histological studies demonstrated that lung tissue in the fluoxetine treatment group morphologically appears to be similar to the pseudoglandular phase, whereas the control group lungs experienced more development. CONCLUSION: According to the upregulated expression of HoxB5 concerning histological findings, results of the present study showed that fluoxetine can influence lung growth and may in turn lead to delay in lung development. So establishment of studies to identify the effects of antidepressant drugs during pregnancy is deserved.
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spelling pubmed-50985222016-11-14 The expression of HoxB5 and SPC in neonatal rat lung after exposure to fluoxetine Taghizadeh, Razieh Taghipour, Zahra Karimi, Akbar Shamsizadeh, Ali Taghavi, Mohammad Mohsen Shariati, Mahdi Shabanizadeh, Ahmad Jafari Naveh, Hamid Reza Bidaki, Reza Aminzadeh, Fariba Drug Des Devel Ther Original Research OBJECTIVE: Approximately 10% of pregnant women suffer from pregnancy-associated depression. Fluoxetine, as a selective serotonin reuptake inhibitor, is being employed as a therapy for depressive disorders. The present study aimed to determine the effects of fluoxetine on neonatal lung development. METHODS: Thirty pregnant Wistar rats (weighing 200–250 g) were treated daily with 7 mg/kg fluoxetine from gestation day 0 to gestation day 21, via gavage. The control group received a similar volume of distilled water only. Following delivery, the newborns and their lungs were immediately weighed in both of the groups. The right lung was fixed for histological assessments while the left lung was used for evaluation of the expression of SPC and HoxB5 by the real-time polymerase chain reaction method. RESULTS: Results have indicated that even though the body weight and the number of neonatal rats in both groups were the same, the lung weight of neonates exposed to fluoxetine was significantly different compared to the control group (P<0.05). Expression of both genes was increased, nonetheless, only elevation of HoxB5 was significant (P<0.05). Histological studies demonstrated that lung tissue in the fluoxetine treatment group morphologically appears to be similar to the pseudoglandular phase, whereas the control group lungs experienced more development. CONCLUSION: According to the upregulated expression of HoxB5 concerning histological findings, results of the present study showed that fluoxetine can influence lung growth and may in turn lead to delay in lung development. So establishment of studies to identify the effects of antidepressant drugs during pregnancy is deserved. Dove Medical Press 2016-11-02 /pmc/articles/PMC5098522/ /pubmed/27843293 http://dx.doi.org/10.2147/DDDT.S109473 Text en © 2016 Taghizadeh et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Taghizadeh, Razieh
Taghipour, Zahra
Karimi, Akbar
Shamsizadeh, Ali
Taghavi, Mohammad Mohsen
Shariati, Mahdi
Shabanizadeh, Ahmad
Jafari Naveh, Hamid Reza
Bidaki, Reza
Aminzadeh, Fariba
The expression of HoxB5 and SPC in neonatal rat lung after exposure to fluoxetine
title The expression of HoxB5 and SPC in neonatal rat lung after exposure to fluoxetine
title_full The expression of HoxB5 and SPC in neonatal rat lung after exposure to fluoxetine
title_fullStr The expression of HoxB5 and SPC in neonatal rat lung after exposure to fluoxetine
title_full_unstemmed The expression of HoxB5 and SPC in neonatal rat lung after exposure to fluoxetine
title_short The expression of HoxB5 and SPC in neonatal rat lung after exposure to fluoxetine
title_sort expression of hoxb5 and spc in neonatal rat lung after exposure to fluoxetine
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098522/
https://www.ncbi.nlm.nih.gov/pubmed/27843293
http://dx.doi.org/10.2147/DDDT.S109473
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