Cargando…

Endoperoxide antimalarials: development, structural diversity and pharmacodynamic aspects with reference to 1,2,4-trioxane-based structural scaffold

Malaria disease continues to be a major health problem worldwide due to the emergence of multidrug-resistant strains of Plasmodium falciparum. In recent days, artemisinin (ART)-based drugs and combination therapies remain the drugs of choice for resistant P. falciparum malaria. However, resistance t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rudrapal, Mithun, Chetia, Dipak
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098533/ https://www.ncbi.nlm.nih.gov/pubmed/27843298 http://dx.doi.org/10.2147/DDDT.S118116

Ejemplares similares

Novel series of 1,2,4-trioxane derivatives as antimalarial agents
por: Rudrapal, Mithun, et al.
Publicado: (2017)

Design, molecular docking, drug-likeness, and molecular dynamics studies of 1,2,4-trioxane derivatives as novel Plasmodium falciparum falcipain-2 (FP-2) inhibitors
por: Ghosh, Subham, et al.
Publicado: (2021)

Solvent and Substituent Effects on the Thermolysis of Antimalarial Fluorophenyl Substituted 1,2.4-Trioxanes
por: Cafferata, Lazaro F. R., et al.
Publicado: (2003)

Mechanistic Evaluation of the Stability of Arylvinyl-1,2,4-trioxanes under Acidic Conditions for Their Oral Administration as an Antimalarial Drug
por: Kumari, Akriti, et al.
Publicado: (2022)

Synthetic Approaches to Mono- and Bicyclic Perortho-Esters with a Central 1,2,4-Trioxane Ring as the Privileged Lead Structure in Antimalarial and Antitumor-Active Peroxides and Clarification of the Peroxide Relevance
por: Griesbeck, Axel G., et al.
Publicado: (2017)

Solvent and Substituent Effects on the Kinetics of Thermolysis of cis-Fused 1,2,4-Trioxanes
por: Cafferata, Lázaro F. R., et al.
Publicado: (2001)

Pharmacokinetic Study and Bioavailability of a Novel Synthetic Trioxane Antimalarial Compound 97/63 in Rats
por: Kushwaha, Hari Narayan, et al.
Publicado: (2014)

The Role of the Iron Protoporphyrins Heme and Hematin in the Antimalarial Activity of Endoperoxide Drugs
por: Quadros, Helenita C., et al.
Publicado: (2022)

Advocacy for the Medicinal Plant Artabotrys hexapetalus (Yingzhao) and Antimalarial Yingzhaosu Endoperoxides
por: Bailly, Christian, et al.
Publicado: (2022)

Antimalarial effect of synthetic endoperoxide on synchronized Plasmodium chabaudi infected mice
por: Aly, Nagwa S. M., et al.
Publicado: (2023)

Structural basis for endoperoxide-forming oxygenases
por: Mori, Takahiro, et al.
Publicado: (2022)

Biological Evaluation in Resistant Cancer Cells and Study of Mechanism of Action of Arylvinyl-1,2,4-Trioxanes
por: Ng, Jerome P. L., et al.
Publicado: (2022)

Synthesis of spiroannulated and 3-arylated 1,2,4-trioxanes from mesitylol and methyl 4-hydroxytiglate by photooxygenation and peroxyacetalization
por: Griesbeck, Axel G, et al.
Publicado: (2010)

Reduction of the Double Bond of 6-Arylvinyl-1,2,4-trioxanes Leads to a Remarkable Increase in Their Antimalarial Activity against Multidrug-Resistant Plasmodium yoelii nigeriensis in a Swiss Mice Model
por: Hassam, Mohammad, et al.
Publicado: (2021)

Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide–Pyrazole Hybrids
por: Amado, Patrícia S. M., et al.
Publicado: (2022)

Synthesis and structure of 2,4,6-tricyclobutyl-1,3,5-trioxane
por: Shorunov, Sergey V., et al.
Publicado: (2019)

Relative and Absolute Stereochemistry of Diacarperoxides: Antimalarial Norditerpene Endoperoxides from Marine Sponge Diacarnus megaspinorhabdosa
por: Yang, Fan, et al.
Publicado: (2014)

Artefenomel Regioisomer RLA-3107 Is a Promising Lead for the Discovery of Next-Generation Endoperoxide Antimalarials
por: Blank, Brian R., et al.
Publicado: (2023)

Time Course of the Changes in Novel Trioxane Antimalarial 99/411 Pharmacokinetics upon Antiepileptic Drugs Co-Administration in SD Rats
por: Singh, Yeshwant, et al.
Publicado: (2014)

The interaction of heme with plakortin and a synthetic endoperoxide analogue: new insights into the heme-activated antimalarial mechanism
por: Persico, Marco, et al.
Publicado: (2017)

Assessment of pharmacokinetic compatibility of short acting CDRI candidate trioxane derivative, 99–411, with long acting prescription antimalarials, lumefantrine and piperaquine
por: Taneja, Isha, et al.
Publicado: (2015)

Antiviral phytocompounds “ellagic acid” and “(+)-sesamin” of Bridelia retusa identified as potential inhibitors of SARS-CoV-2 3CL pro using extensive molecular docking, molecular dynamics simulation studies, binding free energy calculations, and bioactivity prediction
por: Umar, Abd. Kakhar, et al.
Publicado: (2022)

Marine Terpenic Endoperoxides
por: Torres-García, Irene, et al.
Publicado: (2021)

Antileishmanial Anthracene Endoperoxides: Efficacy In Vitro, Mechanisms and Structure-Activity Relationships
por: Machin, Laura, et al.
Publicado: (2022)

Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity
por: Dembitsky, Valery M., et al.
Publicado: (2021)

Rubrene endoperoxide acetone monosolvate
por: Shinashi, Kiyoaki, et al.
Publicado: (2012)

Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial
por: Phyo, Aung Pyae, et al.
Publicado: (2016)

Redetermination of 2,4,6-tricyclohexyl-1,3,5-trioxane
por: Moreno-Fuquen, Rodolfo, et al.
Publicado: (2008)

Integrated computational approach towards repurposing of antimalarial drug against SARS-CoV-2 main protease
por: Gogoi, Neelutpal, et al.
Publicado: (2022)

Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate
por: Wein, S, et al.
Publicado: (2012)

Pharmacokinetic and Pharmacodynamic Considerations in Antimalarial Dose Optimization
por: White, Nicholas J.
Publicado: (2013)

Repurposing of phytomedicine-derived bioactive compounds with promising anti-SARS-CoV-2 potential: Molecular docking, MD simulation and drug-likeness/ADMET studies
por: Rudrapal, Mithun, et al.
Publicado: (2022)

1,2,4-Trioxolane and 1,2,4,5-Tetraoxane Endoperoxides against Old-World Leishmania Parasites: In Vitro Activity and Mode of Action
por: Mendes, Andreia, et al.
Publicado: (2022)

Short‐Chained Anthracene Strapped Porphyrins and their Endoperoxides
por: Callaghan, Susan, et al.
Publicado: (2020)

A New Alkamide with an Endoperoxide Structure from Acmella ciliata (Asteraceae) and Its in Vitro Antiplasmodial Activity
por: Silveira, Narjara, et al.
Publicado: (2016)

Artemisinin Derivatives and Synthetic Trioxane Trigger Apoptotic Cell Death in Asexual Stages of Plasmodium
por: Gunjan, Sarika, et al.
Publicado: (2018)

The Dynamical Behavior of the s-Trioxane Radical Cation—A Low-Temperature EPR and Theoretical Study
por: Naumov, Sergej S., et al.
Publicado: (2014)

Activation of Anthracene Endoperoxides in Leishmania and Impairment of Mitochondrial Functions
por: Geroldinger, Gerald, et al.
Publicado: (2018)

Time-Resolved Insight into the Photosensitized Generation of Singlet Oxygen in Endoperoxides
por: Martínez-Fernández, Lara, et al.
Publicado: (2014)

Exploring endoperoxides as a new entry for the synthesis of branched azasugars
por: Domeyer, Svenja, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_72m96d7tenq9e1volcvpnbuehk