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Antiplatelet and Antithrombotic Effects of the Extract of Lindera obtusiloba Leaves
Lindera obtusiloba has been used in traditional herbal medicine for the treatment of blood stasis and inflammation. The leaves of Lindera obtusiloba have been reported to exhibit various physiological activities. However, there is little information available on their antiplatelet and antithrombotic...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Applied Pharmacology
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098546/ https://www.ncbi.nlm.nih.gov/pubmed/27302963 http://dx.doi.org/10.4062/biomolther.2016.021 |
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author | Kim, Jun Ho Lee, Jaemin Kang, Soouk Moon, Hongsik Chung, Kyung Ho Kim, Kyoung Rak |
author_facet | Kim, Jun Ho Lee, Jaemin Kang, Soouk Moon, Hongsik Chung, Kyung Ho Kim, Kyoung Rak |
author_sort | Kim, Jun Ho |
collection | PubMed |
description | Lindera obtusiloba has been used in traditional herbal medicine for the treatment of blood stasis and inflammation. The leaves of Lindera obtusiloba have been reported to exhibit various physiological activities. However, there is little information available on their antiplatelet and antithrombotic activities. Thus, the present study aimed to evaluate the effect of Lindera obtusiloba leaf extract (LLE) on platelet activities, coagulation and thromboembolism. In a platelet aggregation study, LLE significantly inhibited various agonist-induced platelet aggregations in vitro and ex vivo. Furthermore, LLE significantly inhibited collagen-induced thromboxane A2 (TXA2) production in rat platelets. In addition, oral administration of LLE was protective in a mouse model of pulmonary thromboembolism induced by intravenous injection of a mixture of collagen and epinephrine. Interestingly, LLE did not significantly alter prothrombin time (PT) and activated partial thromboplastin time (aPTT). This study indicates that the antithrombotic effects of LLE might be due to its antiplatelet activities rather than anticoagulation. Taken together, these results suggest that LLE may be a candidate preventive and therapeutic agent in cardiovascular diseases associated with platelet hyperactivity. |
format | Online Article Text |
id | pubmed-5098546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Society of Applied Pharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-50985462016-11-14 Antiplatelet and Antithrombotic Effects of the Extract of Lindera obtusiloba Leaves Kim, Jun Ho Lee, Jaemin Kang, Soouk Moon, Hongsik Chung, Kyung Ho Kim, Kyoung Rak Biomol Ther (Seoul) Original Article Lindera obtusiloba has been used in traditional herbal medicine for the treatment of blood stasis and inflammation. The leaves of Lindera obtusiloba have been reported to exhibit various physiological activities. However, there is little information available on their antiplatelet and antithrombotic activities. Thus, the present study aimed to evaluate the effect of Lindera obtusiloba leaf extract (LLE) on platelet activities, coagulation and thromboembolism. In a platelet aggregation study, LLE significantly inhibited various agonist-induced platelet aggregations in vitro and ex vivo. Furthermore, LLE significantly inhibited collagen-induced thromboxane A2 (TXA2) production in rat platelets. In addition, oral administration of LLE was protective in a mouse model of pulmonary thromboembolism induced by intravenous injection of a mixture of collagen and epinephrine. Interestingly, LLE did not significantly alter prothrombin time (PT) and activated partial thromboplastin time (aPTT). This study indicates that the antithrombotic effects of LLE might be due to its antiplatelet activities rather than anticoagulation. Taken together, these results suggest that LLE may be a candidate preventive and therapeutic agent in cardiovascular diseases associated with platelet hyperactivity. The Korean Society of Applied Pharmacology 2016-11 2016-11-01 /pmc/articles/PMC5098546/ /pubmed/27302963 http://dx.doi.org/10.4062/biomolther.2016.021 Text en Copyright ©2016, The Korean Society of Applied Pharmacology http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Jun Ho Lee, Jaemin Kang, Soouk Moon, Hongsik Chung, Kyung Ho Kim, Kyoung Rak Antiplatelet and Antithrombotic Effects of the Extract of Lindera obtusiloba Leaves |
title | Antiplatelet and Antithrombotic Effects of the Extract of Lindera obtusiloba Leaves |
title_full | Antiplatelet and Antithrombotic Effects of the Extract of Lindera obtusiloba Leaves |
title_fullStr | Antiplatelet and Antithrombotic Effects of the Extract of Lindera obtusiloba Leaves |
title_full_unstemmed | Antiplatelet and Antithrombotic Effects of the Extract of Lindera obtusiloba Leaves |
title_short | Antiplatelet and Antithrombotic Effects of the Extract of Lindera obtusiloba Leaves |
title_sort | antiplatelet and antithrombotic effects of the extract of lindera obtusiloba leaves |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098546/ https://www.ncbi.nlm.nih.gov/pubmed/27302963 http://dx.doi.org/10.4062/biomolther.2016.021 |
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