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Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33
Genome-wide association (GWA) studies have thus far identified 10 loci at which common variants influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional loci, we conducted a meta-analysis of three GWA studies from the UK totalling 3,334 cases and 4,628 contro...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098601/ https://www.ncbi.nlm.nih.gov/pubmed/20972440 http://dx.doi.org/10.1038/ng.670 |
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| author | Houlston, Richard S Cheadle, Jeremy Dobbins, Sara E Tenesa, Albert Jones, Angela M Howarth, Kimberley Spain, Sarah L Broderick, Peter Domingo, Enric Farrington, Susan Prendergast, James GD Pittman, Alan M Theodoratou, Evi Smith, Christopher G Olver, Bianca Walther, Axel Barnetson, Rebecca A Churchman, Michael Jaeger, Emma EM Penegar, Steven Barclay, Ella Martin, Lynn Gorman, Maggie Mager, Rachel Johnstone, Elaine Midgley, Rachel Niittymäki, Iina Tuupanen, Sari Colley, James Idziaszczyk, Shelley Thomas, Huw JM Lucassen, Anneke M Evans, D Gareth R Maher, Eamonn R Maughan, Timothy Dimas, Antigone Dermitzakis, Emmanouil Cazier, Jean-Baptiste Aaltonen, Lauri A Pharoah, Paul Kerr, David J Carvajal-Carmona, Luis G Campbell, Harry Dunlop, Malcolm G Tomlinson, Ian PM |
| author_facet | Houlston, Richard S Cheadle, Jeremy Dobbins, Sara E Tenesa, Albert Jones, Angela M Howarth, Kimberley Spain, Sarah L Broderick, Peter Domingo, Enric Farrington, Susan Prendergast, James GD Pittman, Alan M Theodoratou, Evi Smith, Christopher G Olver, Bianca Walther, Axel Barnetson, Rebecca A Churchman, Michael Jaeger, Emma EM Penegar, Steven Barclay, Ella Martin, Lynn Gorman, Maggie Mager, Rachel Johnstone, Elaine Midgley, Rachel Niittymäki, Iina Tuupanen, Sari Colley, James Idziaszczyk, Shelley Thomas, Huw JM Lucassen, Anneke M Evans, D Gareth R Maher, Eamonn R Maughan, Timothy Dimas, Antigone Dermitzakis, Emmanouil Cazier, Jean-Baptiste Aaltonen, Lauri A Pharoah, Paul Kerr, David J Carvajal-Carmona, Luis G Campbell, Harry Dunlop, Malcolm G Tomlinson, Ian PM |
| author_sort | Houlston, Richard S |
| collection | PubMed |
| description | Genome-wide association (GWA) studies have thus far identified 10 loci at which common variants influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional loci, we conducted a meta-analysis of three GWA studies from the UK totalling 3,334 cases and 4,628 controls, followed by multiple validation analyses, involving a total of 18,095 CRC cases and 20,197 controls. We identified new associations at 4 CRC risk loci: 1q41 (rs6691170, OR=1.06, P=9.55x10(-10); rs6687758, OR=1.09, P=2.27x10(-9)); 3q26.2 (rs10936599, OR=0.93, P=3.39x10(-8)); 12q13.13 (rs11169552, OR=0.92, P=1.89x10(-10); rs7136702, OR=1.06, P=4.02=x10(-8)); and 20q13.33 (rs4925386, OR=0.93, P=1.89x10(-10)). As well as identifying multiple new CRC risk loci this analysis provides evidence that additional CRC-associated variants of similar effect size remain to be discovered. |
| format | Online Article Text |
| id | pubmed-5098601 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-50986012016-11-07 Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33 Houlston, Richard S Cheadle, Jeremy Dobbins, Sara E Tenesa, Albert Jones, Angela M Howarth, Kimberley Spain, Sarah L Broderick, Peter Domingo, Enric Farrington, Susan Prendergast, James GD Pittman, Alan M Theodoratou, Evi Smith, Christopher G Olver, Bianca Walther, Axel Barnetson, Rebecca A Churchman, Michael Jaeger, Emma EM Penegar, Steven Barclay, Ella Martin, Lynn Gorman, Maggie Mager, Rachel Johnstone, Elaine Midgley, Rachel Niittymäki, Iina Tuupanen, Sari Colley, James Idziaszczyk, Shelley Thomas, Huw JM Lucassen, Anneke M Evans, D Gareth R Maher, Eamonn R Maughan, Timothy Dimas, Antigone Dermitzakis, Emmanouil Cazier, Jean-Baptiste Aaltonen, Lauri A Pharoah, Paul Kerr, David J Carvajal-Carmona, Luis G Campbell, Harry Dunlop, Malcolm G Tomlinson, Ian PM Nat Genet Article Genome-wide association (GWA) studies have thus far identified 10 loci at which common variants influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional loci, we conducted a meta-analysis of three GWA studies from the UK totalling 3,334 cases and 4,628 controls, followed by multiple validation analyses, involving a total of 18,095 CRC cases and 20,197 controls. We identified new associations at 4 CRC risk loci: 1q41 (rs6691170, OR=1.06, P=9.55x10(-10); rs6687758, OR=1.09, P=2.27x10(-9)); 3q26.2 (rs10936599, OR=0.93, P=3.39x10(-8)); 12q13.13 (rs11169552, OR=0.92, P=1.89x10(-10); rs7136702, OR=1.06, P=4.02=x10(-8)); and 20q13.33 (rs4925386, OR=0.93, P=1.89x10(-10)). As well as identifying multiple new CRC risk loci this analysis provides evidence that additional CRC-associated variants of similar effect size remain to be discovered. 2010-10-24 2010-11 /pmc/articles/PMC5098601/ /pubmed/20972440 http://dx.doi.org/10.1038/ng.670 Text en Users may view, print, copy, download and text and datamine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Houlston, Richard S Cheadle, Jeremy Dobbins, Sara E Tenesa, Albert Jones, Angela M Howarth, Kimberley Spain, Sarah L Broderick, Peter Domingo, Enric Farrington, Susan Prendergast, James GD Pittman, Alan M Theodoratou, Evi Smith, Christopher G Olver, Bianca Walther, Axel Barnetson, Rebecca A Churchman, Michael Jaeger, Emma EM Penegar, Steven Barclay, Ella Martin, Lynn Gorman, Maggie Mager, Rachel Johnstone, Elaine Midgley, Rachel Niittymäki, Iina Tuupanen, Sari Colley, James Idziaszczyk, Shelley Thomas, Huw JM Lucassen, Anneke M Evans, D Gareth R Maher, Eamonn R Maughan, Timothy Dimas, Antigone Dermitzakis, Emmanouil Cazier, Jean-Baptiste Aaltonen, Lauri A Pharoah, Paul Kerr, David J Carvajal-Carmona, Luis G Campbell, Harry Dunlop, Malcolm G Tomlinson, Ian PM Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33 |
| title | Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33 |
| title_full | Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33 |
| title_fullStr | Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33 |
| title_full_unstemmed | Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33 |
| title_short | Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33 |
| title_sort | meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33 |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098601/ https://www.ncbi.nlm.nih.gov/pubmed/20972440 http://dx.doi.org/10.1038/ng.670 |
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